Gene therapy is here. Right now. We can do it. Luxturna for RPE65 retinopathy is approved and many other examples have extremely compelling preclinical data. Most recent one was Sarepta's DMC micro-dystrophin AAV vector.
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Preclinical data on gene therapy has a long history of later trials not making it to the clinic....
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Right, but do have approvals right now. And the same technology that worked in approvals is being applied in those preclinical studies. Not to mention gene-therapy-esque treatments (e.g. RNAi) that are also FDA approved from Alnylyam in TTR Amyloidosis.
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The bottlenecks have shifted - and I agree that gene therapy as a "universal cure to a shit ton of diseases" is not here. But the bottleneck isn't oncogenesis (AAVs are episomal not ingtegrated) or immunogenicity (so long as you don't have to redose many times), it's delivery.
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Not delivery per se but clinical delivery at scale in real healthcare settings. China approved a gene therapy treatment for head and neck cancer almost 1.5 decades ago. No news since. Scaling is the challenge sadly. The promise isn’t in doubt.
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I think
@shefaly captures what I meant much more elegantly than I :)
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Arthur Clarke on what we expected the future to hold and what actually came.pic.twitter.com/Smp1181Sgr
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Would love to see his list of expected but didnt happen (e.g. flying cars)
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What about AI?
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The defintion of AI (outside of AGI) keeps shifting to be harder as well :)
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But how many years away do you think AI prime time is?
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I think this has a set of relevant views https://www.amazon.com/dp/B00LOOCGB2/ref=dp-kindle-redirect?_encoding=UTF8&btkr=1 …
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Cool thanks!
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I would add quantim computing to the list
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Definitely worth adding!
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MEMS printed electronics are already mainstream, in just about every phone
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I was thinking more about microfluidics or the like. Fair point - another mainstream use of MEMs is aribags. But was thinking more of the other applications always pointed to in materials science departments :)
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While there's plenty of real MEMS: microphones, DLP, g sensors, even as an MSE ugrad 15+ years ago, it was all about the microfluidics from profs! -
Those alcohol testers are mems
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MEMS? They are in every smartphone in the world (microphones, gyros, accelerometers) as well as projectors, cameras, printers, health tech... And have been for years... Can't imagine more prime time than that. Can you clarify?
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Ah, I see your follow-up. Yes, that makes sense. But I think the question is really more like "what's the point?". Many of the famous MEMS tech "solutions" (like, say, in-body micro fluid delivery in cancer treatment) have been solved by lower-tech or completely different tech.
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Fair point. However a lot of the “biggies” to be solved from 20 years ago are the same today (lab on a chip, chem synthesis, drug delivery patches etc). Don’t get me wrong, I think we will get there someday-it’s just the timeline to get there is always the same....
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I too am super-excited/optimistic by this tech btw. In fact, my degree (20 years ago now) was very nearly in nano machine technology. Was way too early back then as it kinda is now in the sense you meant in your post. Ended up doing bigger mechanical engineering instead.
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