"1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone"https://twitter.com/Mendelian_lit/status/857900594920431616 …
Here does "genetically instrumented" mean "using genotype features as instruments in IV estimation of BMI effect size" ?
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yeah I mean I can refer you to explainers of mendelian randomization if interested, here we take advantage of independent segregation to...
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treat gene variants for X phenotype as unconfounded "treatments" for Y phenotype to see if the association is causal or not. I think it's...
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similar to the instrumental variable concept in economics? You need several assumptions I haven't checked for this specific paper like...
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taking into account pleiotropy (one variant, several effects) but in general if well done it's a robust method
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Yes I think that's similar. Thanks for the summary--will try to parse MR when a bit more awake.
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I find it very funny because as far as I can recall they debunk as much as they confirm, but people in both extremes see it as evil genetic…
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determinist false negatives or production of PC results about the environment mattering.Anyways I found http://ajcn.nutrition.org/content/early/2016/03/09/ajcn.115.118216.full.pdf+html … in bookmarks
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I can recall a shorter explainer (showing you *can't* use this method to estimate medical cost of higher BMI because one of the assumptions…
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