"1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone"https://twitter.com/Mendelian_lit/status/857900594920431616 …
Here does "genetically instrumented" mean "using genotype features as instruments in IV estimation of BMI effect size" ?
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yeah I mean I can refer you to explainers of mendelian randomization if interested, here we take advantage of independent segregation to...
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treat gene variants for X phenotype as unconfounded "treatments" for Y phenotype to see if the association is causal or not. I think it's...
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