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eigenrobot's profile
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eigenrobot
eigenrobot
@eigenrobot

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eigenrobot

@eigenrobot

robot. friend.

eigenrobot.substack.com
Joined July 2013

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    1. shakoist ~locpub‏ @cauchyfriend Aug 26
      Replying to @eigenrobot @wrongbutkind

      If I wanted to make a real argument, I think there is something here like "Thinking like a state" but instead "Thinking like a MRNA Vaccine" -- it captures the structure as we understand it, but maybe misses things the human doesn't see. Or maybe not, I don't know immunology.

      1 reply 0 retweets 5 likes
    2. eigenrobot‏ @eigenrobot Aug 26
      Replying to @cauchyfriend @wrongbutkind

      i mostly slept through it because it was always at the end of my cell bio courses and i was usually exhausted by end of semester my simple model is 1. whole virus provides many antigen options for immune response 2. mRNA provides a lot of one antigen

      2 replies 0 retweets 15 likes
    3. eigenrobot‏ @eigenrobot Aug 26
      Replying to @eigenrobot @cauchyfriend @wrongbutkind

      so assuming this is correct issue is ok how much does (1) speed/intensity of future response differ from a ton of spike protein training vs. broad exposure to entire virus, and (2) how is this the first attenuated by difference in spike protein between alpha and delta

      1 reply 0 retweets 12 likes
    4. eigenrobot‏ @eigenrobot Aug 26
      Replying to @eigenrobot @cauchyfriend @wrongbutkind

      hunch is assuming not that much difference in effectiveness of natural immunity vs vaccinated, and then drift in spike protein may cut any advantage of vaccine again I have no idea how to set these parameters, pretty naive take on this

      2 replies 0 retweets 11 likes
    5. eigenrobot‏ @eigenrobot Aug 26
      Replying to @eigenrobot @cauchyfriend @wrongbutkind

      I assume @halvorz can explain why I am wrong, I am guessing that there exist two errors

      3 replies 0 retweets 9 likes
    6. halvorz ¯\_(ツ)_/¯‏ @halvorz Aug 26
      Replying to @eigenrobot @cauchyfriend @wrongbutkind

      priors pretty strongly against this because 1) higher neutralizing antibody titre raised by the mRNA vaccines compared to infection 2) Delta is not *that* immunologically different from previous variants, biggest advantage is speed of replication, not immune escape

      1 reply 2 retweets 41 likes
    7. halvorz ¯\_(ツ)_/¯‏ @halvorz Aug 26
      Replying to @halvorz @eigenrobot and

      3) main advantage of infection would be T-cell response (other viral proteins are not on viral surface, antibodies can't see 'em), which is slower than antibody response so shouldn't really help with faster replication kinetics

      3 replies 0 retweets 31 likes
    8. eigenrobot‏ @eigenrobot Aug 26
      Replying to @halvorz @cauchyfriend @wrongbutkind

      im delighted i was as close to being correct as I was thanks :)

      1 reply 0 retweets 7 likes
    9. all-paca father‏ @OneEyedAlpaca Aug 26
      Replying to @eigenrobot @halvorz and

      all-paca father Retweeted all-paca father

      uh oh, your power growshttps://twitter.com/OneEyedAlpaca/status/1429552886636109831?s=20 …

      all-paca father added,

      all-paca father @OneEyedAlpaca
      Replying to @eigenrobot
      we have given the robot Too Much power
      1 reply 0 retweets 4 likes
    10. TubunMuzuru‏ @TubunMuzuru Aug 26
      Replying to @OneEyedAlpaca @eigenrobot and

      The eigenrobot... knows more than you. Also more than me. I, for one, welcome our new eigenlord.

      3 replies 0 retweets 5 likes
      eigenrobot‏ @eigenrobot Aug 26
      Replying to @TubunMuzuru @OneEyedAlpaca and

      i assure you im quite dumb 😨

      8:03 PM - 26 Aug 2021
      • 6 Likes
      • halvorz ¯\_(ツ)_/¯ Sernie Banders #8 shakoist ~locpub TubunMuzuru all-paca father
      2 replies 0 retweets 6 likes
        1. TubunMuzuru‏ @TubunMuzuru Aug 26
          Replying to @eigenrobot @OneEyedAlpaca and

          Defensive camouflage.

          0 replies 0 retweets 1 like
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        1. all-paca father‏ @OneEyedAlpaca Aug 26
          Replying to @eigenrobot @TubunMuzuru and

          i'm saving this for future shenanigans

          0 replies 0 retweets 3 likes
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