I wouldnt be too shocked
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Idk you sound right, and isn’t that what counts?
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priors pretty strongly against this because 1) higher neutralizing antibody titre raised by the mRNA vaccines compared to infection 2) Delta is not *that* immunologically different from previous variants, biggest advantage is speed of replication, not immune escape
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3) main advantage of infection would be T-cell response (other viral proteins are not on viral surface, antibodies can't see 'em), which is slower than antibody response so shouldn't really help with faster replication kinetics
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Study is cool, but a couple design issues seem obvious: 1) lack of prior positive test != never infected in the pre-vaccine period and 2) differences in testing behaviour. Analyses could be limited to test-negative in the same way VE cohorts are done.
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