(occasionally for certain enzymes if the folding goes very badly it turns itself into an enzyme whose function is to turn working enzymes into misfolded enzymes and oh shit now you are going to die)https://science.sciencemag.org/content/373/6554/475 …
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all of this is to say that the sons of bitches who published this have managed to take an unfathomably complex and incredibly delicate molecular machine developed over god knows how many millions of years such that its orientation is the same in all known life,
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and somehow managed to get this entire 3D configuration perfectly inverted to work on DNA that is DNA it just spins the wrong way im in awe
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eigenrobot Retweeted eigenrobot
a few end notes the reason they want to make a "DNase" ie an enzyme that chops up DNA is because all of the existing DNases only work on D-DNA and so if they keep making this shit it will be hard to dispose of elegantly I guess?https://twitter.com/eigenrobot/status/1420952819901755393?s=19 …
eigenrobot added,
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RNA polymerase is a molecule that goes down a DNA strand and translates the DNA into instructions for making protein. they made a left hand version of this too apparentlypic.twitter.com/IVRzAxYqbf
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ribosomes are enormous multi-part protein machines that take RNA and turn it into proteins left is sort of what ours looks like, right is a bacterial version I guess they're making these nextpic.twitter.com/uE9ZMFNsyf
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overall I dont know what the fuck is going on but the fact that this is not only possible but an accomplished feat is making me think that molecular biology is way more advanced than is commonly understood and things are gonna get Weird real real fast good luck out there
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will try to answer questions, please keep in mind that I was never a great biology student and I haven't studied anything since the mid aughts
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eigenrobot Retweeted NLRG Loves Recursive Guises
"why is this named so and so" biology is a field full of sickos. for example they named a gene that mutates and kills people "Sonic Hedgehog" as a joke and now doctors have to tell moms their kid is dying because of a sonic hedgehog mutationhttps://twitter.com/NLRG_/status/1420965217060655106?s=19 …
eigenrobot added,
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theres another protein that stops it from functioning and that one is called "Robotnikinin" biologists have got to be stopped
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Replying to @costa11235
no I legitimately am delighted theyre having so much fun
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