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eigenrobot's profile
eigenrobot
eigenrobot
eigenrobot
@eigenrobot

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eigenrobot

@eigenrobot

robot. friend.

eigenrobot.substack.com
Joined July 2013

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    1. eigenrobot‏ @eigenrobot Jul 29

      blah blah information storage who cares ok so heres whats up these are DNA polymerases a DNA polymerase is an enzyme (complex? I havent studied this in like fifteen years). what it does basically is it copies strands of dna https://twitter.com/postpostpostr/status/1420953150849228802?s=19 …pic.twitter.com/bbWjaq9Afy

      1 reply 9 retweets 125 likes
      Show this thread
    2. eigenrobot‏ @eigenrobot Jul 29

      all the DNA that operates in your body is whats called "D-DNA" D for "dexter" ie right-handed basically its coiled in a specific direction, ie from a standard axis it coils "right" as far as i know all DNA in living creatures is D-DNA

      13 replies 3 retweets 119 likes
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    3. eigenrobot‏ @eigenrobot Jul 29

      its often the case in organic chemistry and biology that a molecule will be "chiral" ie "handed" the basic idea is that if you were to take a mirror image of a chiral molecule and superimpose it on the opposite mirror image they wouldnt match uphttps://en.m.wikipedia.org/wiki/Chirality 

      2 replies 2 retweets 102 likes
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    4. eigenrobot‏ @eigenrobot Jul 29

      this is boring as hell but it has a lot of implications for biochemistry. among other things because enzymes in your body operate in three dimensions, typically only one version of a molecule will be produced in a given enzymatic reaction

      5 replies 3 retweets 99 likes
      Show this thread
    5. eigenrobot‏ @eigenrobot Jul 29

      this is why for example it would be very difficult for me to synthesize cocaine in my crawlspace. cocaine is not a complicated molecule but its super-chiral and unless I used enzymes to make it most of the cocaine produced wouldnt actually work in my bodypic.twitter.com/ZDF15oMIvI

      4 replies 1 retweet 108 likes
      Show this thread
    6. eigenrobot‏ @eigenrobot Jul 29

      but because the cocoa plant uses enzymes to make cocaine in a specific 3D way all of the cocaine in its leaves is "bioactive", ie when you take a line off a strippers ass 100% of it will match up with various 3D receptors in your brain

      8 replies 4 retweets 155 likes
      Show this thread
    7. eigenrobot‏ @eigenrobot Jul 29

      so why is building an enzyme that copies mirror DNA a big deal well as i mentioned before enzymes typically only work on one specific mirror version (one "isomer") of a molecule because they have a three dimensional operating mechanism and the wrong isomer doesnt fit it

      1 reply 2 retweets 100 likes
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    8. eigenrobot‏ @eigenrobot Jul 29

      take a moment to ponder how ugly complicated this enzyme is. I am reemphasizing that this is a representation of DNA polymerase (most colors) working on copying some DNA (purple bits)pic.twitter.com/fY9t1y61JP

      3 replies 3 retweets 99 likes
      Show this thread
    9. eigenrobot‏ @eigenrobot Jul 29

      keep in mind that the enzyme itself isnt "bulky" exactly. its a long fused thread of amino acids with different areas of chemical sensitivity, and to the extent that the amino acid thread is holding itself together it is often by incredibly tenuous bonds

      1 reply 1 retweet 88 likes
      Show this thread
    10. eigenrobot‏ @eigenrobot Jul 29

      in order to get a protein to even work as intended it has to be printed off of DNA (LONG STORY) and then typically folded into the correct shape by other proteins if the folding goes badly usually it just doesnt work as an enzyme and gets chopped up

      2 replies 1 retweet 87 likes
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      eigenrobot‏ @eigenrobot Jul 29

      (occasionally for certain enzymes if the folding goes very badly it turns itself into an enzyme whose function is to turn working enzymes into misfolded enzymes and oh shit now you are going to die)https://science.sciencemag.org/content/373/6554/475 …

      9:21 PM - 29 Jul 2021
      • 2 Retweets
      • 161 Likes
      • Oscar flux bronze age anon Rush the House Eigil Rischel💎(26879/50000 words) (((theophilus))) Tomáš Kafka Murky Consequences Terrorista de pelúcia 🦕🐊💉
      2 replies 2 retweets 161 likes
        1. New conversation
        2. eigenrobot‏ @eigenrobot Jul 29

          all of this is to say that the sons of bitches who published this have managed to take an unfathomably complex and incredibly delicate molecular machine developed over god knows how many millions of years such that its orientation is the same in all known life,

          4 replies 11 retweets 167 likes
          Show this thread
        3. eigenrobot‏ @eigenrobot Jul 29

          and somehow managed to get this entire 3D configuration perfectly inverted to work on DNA that is DNA it just spins the wrong way im in awe

          6 replies 8 retweets 178 likes
          Show this thread
        4. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted eigenrobot

          a few end notes the reason they want to make a "DNase" ie an enzyme that chops up DNA is because all of the existing DNases only work on D-DNA and so if they keep making this shit it will be hard to dispose of elegantly I guess?https://twitter.com/eigenrobot/status/1420952819901755393?s=19 …

          eigenrobot added,

          eigenrobot @eigenrobot
          ffffffffffffffffffffffffffffffffffffffffff pic.twitter.com/M33XucdfRz
          Show this thread
          8 replies 2 retweets 90 likes
          Show this thread
        5. eigenrobot‏ @eigenrobot Jul 29

          RNA polymerase is a molecule that goes down a DNA strand and translates the DNA into instructions for making protein. they made a left hand version of this too apparentlypic.twitter.com/IVRzAxYqbf

          1 reply 1 retweet 81 likes
          Show this thread
        6. eigenrobot‏ @eigenrobot Jul 29

          ribosomes are enormous multi-part protein machines that take RNA and turn it into proteins left is sort of what ours looks like, right is a bacterial version I guess they're making these nextpic.twitter.com/uE9ZMFNsyf

          2 replies 2 retweets 80 likes
          Show this thread
        7. eigenrobot‏ @eigenrobot Jul 29

          overall I dont know what the fuck is going on but the fact that this is not only possible but an accomplished feat is making me think that molecular biology is way more advanced than is commonly understood and things are gonna get Weird real real fast good luck out there

          11 replies 23 retweets 305 likes
          Show this thread
        8. eigenrobot‏ @eigenrobot Jul 29

          will try to answer questions, please keep in mind that I was never a great biology student and I haven't studied anything since the mid aughts

          5 replies 0 retweets 75 likes
          Show this thread
        9. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted NLRG Loves Recursive Guises

          "why is this named so and so" biology is a field full of sickos. for example they named a gene that mutates and kills people "Sonic Hedgehog" as a joke and now doctors have to tell moms their kid is dying because of a sonic hedgehog mutationhttps://twitter.com/NLRG_/status/1420965217060655106?s=19 …

          eigenrobot added,

          NLRG Loves Recursive Guises @NLRG_
          Replying to @eigenrobot
          why isn't it called DNAase
          13 replies 34 retweets 371 likes
          Show this thread
        10. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted Edward W.

          they would probably be like us but we couldnt eat them. and vice versa. I mean we could but maybe a bunch of the molecules would be the wrong chirality so we couldnt digest them with our enzymeshttps://twitter.com/edwardW2/status/1420966805955223555?s=19 …

          eigenrobot added,

          Edward W. @edwardW2
          Replying to @eigenrobot
          So, just to clarify, with this invention we can now make DNA that spirals the contrary way to the stuff that is in us. If that's the case, one's mind struggles to imagine what would the creatures that would be made of this stuff- if they exist- be like...
          17 replies 4 retweets 113 likes
          Show this thread
        11. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted frye

          my guess is none although it would be weird if idk some invert engineered autotroph escaped and somehow started competing with R-DNA autotrophs and outcompeted them because nothing would eat them and oh shit now we die I guess?https://twitter.com/__frye/status/1420968621732339715?s=19 …

          eigenrobot added,

          frye @__frye
          Replying to @eigenrobot
          what are the odds some inverted chirality particle escapes the lab and kills us all
          7 replies 2 retweets 130 likes
          Show this thread
        12. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted Lone Volts Ahead

          I dont have the slightest clue maybe? I guess inverted prions would probably be saferhttps://twitter.com/LoneVoltsAhead/status/1420968529843658758?s=19 …

          eigenrobot added,

          Lone Volts Ahead @LoneVoltsAhead
          Replying to @eigenrobot
          Any chance this can be used to make gain of function / prion / other dangerous bio research in a safer?
          3 replies 0 retweets 70 likes
          Show this thread
        13. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted

          im inclined to extend benefit of the doubt here because theyre claiming (i) to have actually built something that (ii) doesnt contravene laws of physics as they currently exist and (iii) has no obvious political valence but yes who knows it may be trash https://twitter.com/edibleflowerga1/status/1420964967981928448?s=19 …

          eigenrobot added,

          This Tweet is unavailable.
          4 replies 0 retweets 70 likes
          Show this thread
        14. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted

          update probably real https://twitter.com/halvorz/status/1420976494235602947?s=19 …

          eigenrobot added,

          This Tweet is unavailable.
          1 reply 2 retweets 72 likes
          Show this thread
        15. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted oat

          as far as applications we're like a hop skip and a jump from solving climate change and peak oil in a fell swoop [joke tweet]https://twitter.com/asingleoat/status/1420954835805884416?s=19 …

          eigenrobot added,

          oat @asingleoat
          Replying to @halvorz @sgodofsk
          if we make mirror trees that build their bodies with mirror lignin we can kick start a second Carboniferous
          3 replies 3 retweets 113 likes
          Show this thread
        16. eigenrobot‏ @eigenrobot Jul 29

          eigenrobot Retweeted Prawns Cheese Thaw Must

          gonna pat myself on the back for apparently independently deriving a standard view of the ecological dangers of mirror life so yes if mirror cyanobacteria escaped from a lab we would probably all die fortunately biology labs are proven extremely securehttps://twitter.com/prawncis/status/1420982623048925187?s=19 …

          eigenrobot added,

          Prawns Cheese Thaw Must @prawncis
          Replying to @eigenrobot
          Oopsie pic.twitter.com/SYsDyH1rVP
          36 replies 44 retweets 369 likes
          Show this thread
        17. eigenrobot‏ @eigenrobot Jul 29

          heres the Wikipedia articlehttps://en.m.wikipedia.org/wiki/Mirror_life …

          8 replies 4 retweets 83 likes
          Show this thread
        18. eigenrobot‏ @eigenrobot Jul 29

          an upside of a mirror cyanobacteria escape and population explosion would be that huge quantities of CO2 would be extracted from the atmosphere, solving global warning apart from the mass extinction of R-DNA life there may other minor side effectshttps://en.m.wikipedia.org/wiki/Great_Oxidation_Event …

          9 replies 11 retweets 180 likes
          Show this thread
        19. eigenrobot‏ @eigenrobot Jul 30

          eigenrobot Retweeted ƨꭋɘƨꭋɘvdo

          https://twitter.com/obversers/status/1420992654460997636?s=19 …

          eigenrobot added,

          ƨꭋɘƨꭋɘvdo @obversers
          Replying to @eigenrobot
          come, friend, let us watch the sunrise over waving fields of nroc, and listen to the flocks of dribs singing their backwards songs - let us climb the seerts and feast on their meaningless fruits...
          2 replies 0 retweets 90 likes
          Show this thread
        20. End of conversation

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