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@eigenrobot

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eigenrobot

@eigenrobot

eigenrobot.substack.com
Joined July 2013

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    eigenrobot‏ @eigenrobot 29 Jul 2021

    eigenrobot Retweeted

    holy shit i was already long biotech but this is this is something else. kinda floored. not even sure what one would use it for but the engineering is unreal how even what https://twitter.com/halvorz/status/1420837699749965825 …

    eigenrobot added,

    This Tweet is unavailable.
    8:40 PM - 29 Jul 2021
    • 103 Retweets
    • 587 Likes
    • replicationer panglima geng kapak socialmoth 🎄 anotora Sandor Sid Gander (((theophilus))) Outgoing Hulud Lawrence of Appalachia joni.baboci.net
    38 replies 103 retweets 587 likes
      1. New conversation
      2. eigenrobot‏ @eigenrobot 29 Jul 2021

        ffffffffffffffffffffffffffffffffffffffffffpic.twitter.com/M33XucdfRz

        1 reply 7 retweets 141 likes
        Show this thread
      3. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted  🎀princess 🎀

        I don't have any idea what one would do with this technology because it never even occurred to me that it was possible to do thishttps://twitter.com/NLRG_/status/1420952568386232321?s=19 …

        eigenrobot added,

         🎀princess 🎀 @NLRG_
        Replying to @eigenrobot
        does it have any practical implications or is it just cool
        8 replies 0 retweets 118 likes
        Show this thread
      4. eigenrobot‏ @eigenrobot 29 Jul 2021

        blah blah information storage who cares ok so heres whats up these are DNA polymerases a DNA polymerase is an enzyme (complex? I havent studied this in like fifteen years). what it does basically is it copies strands of dna https://twitter.com/postpostpostr/status/1420953150849228802?s=19 …pic.twitter.com/bbWjaq9Afy

        1 reply 9 retweets 126 likes
        Show this thread
      5. eigenrobot‏ @eigenrobot 29 Jul 2021

        all the DNA that operates in your body is whats called "D-DNA" D for "dexter" ie right-handed basically its coiled in a specific direction, ie from a standard axis it coils "right" as far as i know all DNA in living creatures is D-DNA

        13 replies 3 retweets 118 likes
        Show this thread
      6. eigenrobot‏ @eigenrobot 29 Jul 2021

        its often the case in organic chemistry and biology that a molecule will be "chiral" ie "handed" the basic idea is that if you were to take a mirror image of a chiral molecule and superimpose it on the opposite mirror image they wouldnt match uphttps://en.m.wikipedia.org/wiki/Chirality 

        2 replies 2 retweets 101 likes
        Show this thread
      7. eigenrobot‏ @eigenrobot 29 Jul 2021

        this is boring as hell but it has a lot of implications for biochemistry. among other things because enzymes in your body operate in three dimensions, typically only one version of a molecule will be produced in a given enzymatic reaction

        5 replies 3 retweets 98 likes
        Show this thread
      8. eigenrobot‏ @eigenrobot 29 Jul 2021

        this is why for example it would be very difficult for me to synthesize cocaine in my crawlspace. cocaine is not a complicated molecule but its super-chiral and unless I used enzymes to make it most of the cocaine produced wouldnt actually work in my bodypic.twitter.com/ZDF15oMIvI

        4 replies 1 retweet 106 likes
        Show this thread
      9. eigenrobot‏ @eigenrobot 29 Jul 2021

        but because the cocoa plant uses enzymes to make cocaine in a specific 3D way all of the cocaine in its leaves is "bioactive", ie when you take a line off a strippers ass 100% of it will match up with various 3D receptors in your brain

        8 replies 4 retweets 151 likes
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      10. eigenrobot‏ @eigenrobot 29 Jul 2021

        so why is building an enzyme that copies mirror DNA a big deal well as i mentioned before enzymes typically only work on one specific mirror version (one "isomer") of a molecule because they have a three dimensional operating mechanism and the wrong isomer doesnt fit it

        1 reply 2 retweets 99 likes
        Show this thread
      11. eigenrobot‏ @eigenrobot 29 Jul 2021

        take a moment to ponder how ugly complicated this enzyme is. I am reemphasizing that this is a representation of DNA polymerase (most colors) working on copying some DNA (purple bits)pic.twitter.com/fY9t1y61JP

        3 replies 3 retweets 99 likes
        Show this thread
      12. eigenrobot‏ @eigenrobot 29 Jul 2021

        keep in mind that the enzyme itself isnt "bulky" exactly. its a long fused thread of amino acids with different areas of chemical sensitivity, and to the extent that the amino acid thread is holding itself together it is often by incredibly tenuous bonds

        1 reply 1 retweet 87 likes
        Show this thread
      13. eigenrobot‏ @eigenrobot 29 Jul 2021

        in order to get a protein to even work as intended it has to be printed off of DNA (LONG STORY) and then typically folded into the correct shape by other proteins if the folding goes badly usually it just doesnt work as an enzyme and gets chopped up

        2 replies 1 retweet 86 likes
        Show this thread
      14. eigenrobot‏ @eigenrobot 29 Jul 2021

        (occasionally for certain enzymes if the folding goes very badly it turns itself into an enzyme whose function is to turn working enzymes into misfolded enzymes and oh shit now you are going to die)https://science.sciencemag.org/content/373/6554/475 …

        2 replies 2 retweets 158 likes
        Show this thread
      15. eigenrobot‏ @eigenrobot 29 Jul 2021

        all of this is to say that the sons of bitches who published this have managed to take an unfathomably complex and incredibly delicate molecular machine developed over god knows how many millions of years such that its orientation is the same in all known life,

        4 replies 10 retweets 167 likes
        Show this thread
      16. eigenrobot‏ @eigenrobot 29 Jul 2021

        and somehow managed to get this entire 3D configuration perfectly inverted to work on DNA that is DNA it just spins the wrong way im in awe

        6 replies 7 retweets 176 likes
        Show this thread
      17. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted eigenrobot

        a few end notes the reason they want to make a "DNase" ie an enzyme that chops up DNA is because all of the existing DNases only work on D-DNA and so if they keep making this shit it will be hard to dispose of elegantly I guess?https://twitter.com/eigenrobot/status/1420952819901755393?s=19 …

        eigenrobot added,

        eigenrobot @eigenrobot
        ffffffffffffffffffffffffffffffffffffffffff pic.twitter.com/M33XucdfRz
        Show this thread
        8 replies 2 retweets 90 likes
        Show this thread
      18. eigenrobot‏ @eigenrobot 29 Jul 2021

        RNA polymerase is a molecule that goes down a DNA strand and translates the DNA into instructions for making protein. they made a left hand version of this too apparentlypic.twitter.com/IVRzAxYqbf

        1 reply 1 retweet 81 likes
        Show this thread
      19. eigenrobot‏ @eigenrobot 29 Jul 2021

        ribosomes are enormous multi-part protein machines that take RNA and turn it into proteins left is sort of what ours looks like, right is a bacterial version I guess they're making these nextpic.twitter.com/uE9ZMFNsyf

        2 replies 2 retweets 79 likes
        Show this thread
      20. eigenrobot‏ @eigenrobot 29 Jul 2021

        overall I dont know what the fuck is going on but the fact that this is not only possible but an accomplished feat is making me think that molecular biology is way more advanced than is commonly understood and things are gonna get Weird real real fast good luck out there

        11 replies 23 retweets 301 likes
        Show this thread
      21. eigenrobot‏ @eigenrobot 29 Jul 2021

        will try to answer questions, please keep in mind that I was never a great biology student and I haven't studied anything since the mid aughts

        5 replies 0 retweets 76 likes
        Show this thread
      22. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted  🎀princess 🎀

        "why is this named so and so" biology is a field full of sickos. for example they named a gene that mutates and kills people "Sonic Hedgehog" as a joke and now doctors have to tell moms their kid is dying because of a sonic hedgehog mutationhttps://twitter.com/NLRG_/status/1420965217060655106?s=19 …

        eigenrobot added,

         🎀princess 🎀 @NLRG_
        Replying to @eigenrobot
        why isn't it called DNAase
        13 replies 31 retweets 364 likes
        Show this thread
      23. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted Edward W.

        they would probably be like us but we couldnt eat them. and vice versa. I mean we could but maybe a bunch of the molecules would be the wrong chirality so we couldnt digest them with our enzymeshttps://twitter.com/edwardW2/status/1420966805955223555?s=19 …

        eigenrobot added,

        Edward W. @edwardW2
        Replying to @eigenrobot
        So, just to clarify, with this invention we can now make DNA that spirals the contrary way to the stuff that is in us. If that's the case, one's mind struggles to imagine what would the creatures that would be made of this stuff- if they exist- be like...
        17 replies 3 retweets 112 likes
        Show this thread
      24. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted frye

        my guess is none although it would be weird if idk some invert engineered autotroph escaped and somehow started competing with R-DNA autotrophs and outcompeted them because nothing would eat them and oh shit now we die I guess?https://twitter.com/__frye/status/1420968621732339715?s=19 …

        eigenrobot added,

        frye @__frye
        Replying to @eigenrobot
        what are the odds some inverted chirality particle escapes the lab and kills us all
        7 replies 1 retweet 127 likes
        Show this thread
      25. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted Lone Volts Ahead

        I dont have the slightest clue maybe? I guess inverted prions would probably be saferhttps://twitter.com/LoneVoltsAhead/status/1420968529843658758?s=19 …

        eigenrobot added,

        Lone Volts Ahead @LoneVoltsAhead
        Replying to @eigenrobot
        Any chance this can be used to make gain of function / prion / other dangerous bio research in a safer?
        3 replies 0 retweets 70 likes
        Show this thread
      26. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted

        im inclined to extend benefit of the doubt here because theyre claiming (i) to have actually built something that (ii) doesnt contravene laws of physics as they currently exist and (iii) has no obvious political valence but yes who knows it may be trash https://twitter.com/edibleflowerga1/status/1420964967981928448?s=19 …

        eigenrobot added,

        This Tweet is unavailable.
        4 replies 0 retweets 68 likes
        Show this thread
      27. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted

        update probably real https://twitter.com/halvorz/status/1420976494235602947?s=19 …

        eigenrobot added,

        This Tweet is unavailable.
        1 reply 2 retweets 72 likes
        Show this thread
      28. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted oat

        as far as applications we're like a hop skip and a jump from solving climate change and peak oil in a fell swoop [joke tweet]https://twitter.com/asingleoat/status/1420954835805884416?s=19 …

        eigenrobot added,

        oat @asingleoat
        Replying to @halvorz @sgodofsk
        if we make mirror trees that build their bodies with mirror lignin we can kick start a second Carboniferous
        3 replies 3 retweets 112 likes
        Show this thread
      29. eigenrobot‏ @eigenrobot 29 Jul 2021

        eigenrobot Retweeted Prawns Cheese Thaw Must

        gonna pat myself on the back for apparently independently deriving a standard view of the ecological dangers of mirror life so yes if mirror cyanobacteria escaped from a lab we would probably all die fortunately biology labs are proven extremely securehttps://twitter.com/prawncis/status/1420982623048925187?s=19 …

        eigenrobot added,

        Prawns Cheese Thaw Must @prawncis
        Replying to @eigenrobot
        Oopsie pic.twitter.com/SYsDyH1rVP
        34 replies 42 retweets 363 likes
        Show this thread
      30. eigenrobot‏ @eigenrobot 29 Jul 2021

        heres the Wikipedia articlehttps://en.m.wikipedia.org/wiki/Mirror_life …

        8 replies 3 retweets 82 likes
        Show this thread
      31. eigenrobot‏ @eigenrobot 29 Jul 2021

        an upside of a mirror cyanobacteria escape and population explosion would be that huge quantities of CO2 would be extracted from the atmosphere, solving global warning apart from the mass extinction of R-DNA life there may other minor side effectshttps://en.m.wikipedia.org/wiki/Great_Oxidation_Event …

        9 replies 11 retweets 179 likes
        Show this thread
      32. Show replies

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