hmm are there any religious reasons to oppose gene editing? this seems like a question not answered directly by texts but im sure Jewish and Catholic theologians at least can derive a stance (or several each)https://twitter.com/ellegist/status/1314133656328458243 …
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i lean pretty hard pro crispr wand net, but I worry about those aforementioned considerations
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Church has opinied on this (of course it has!) and is decidedly negative apart from medical cases I wonder if the social understanding of what's "medical" may end up being pretty flexible, thoughhttps://twitter.com/ChrisCroy/status/1314147854802452480?s=19 …
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this is a question that can be investigated and answered,same as pleiotropy/genetic correlations,or quantification of off-target effects as compared to natural mutation rate,etc. I've yet to see any evidence it'd be worrying, but ofc no change to pop should be done with no check
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you might be familiar with the George Church top 10 protective/cool mutations he'd CRISPR a baby with. his lab has more examples but whatever: point is some like immunity to HIV seem to make you more vulnerable to other (softer, maybe worth it?) viruses. others don't!
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skeptical of this guess is that the return would be high enough it would get to be heavily subsidized and possibly mandatory which is differently dark
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if we can gene-edit to select for certain traits with relative safety and efficiency, wouldn’t it be safe to assume we could also re-introduce any needed variation through performing point mutations and such?
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can’t be any more dangerous than leaving it up to stochastic factors like when a polymerase fucks up can it?
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Concern-reducers: A) we'll start making single-edits with easier-to-study side-effects, B) the world is a big place with probably quite variable rollouts across groups over time, C) it'll likely be overly-limited by government. FWIW, I am deep in the "Let it fucking rip" camp.
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that's a real concern on a large enough time scale, I figure but also, natural mutation will be replaced with tinkering, sure as you're born and I do expect reserve populations of basal humans on religious grounds to last quite awhile and variation can be gene-banked
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