If we uplifted (say) cats, would your ethical framework apply to them?
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Are severely mentally impaired humans capable of sin?
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If a person carefully plans drug use and isolates themselves from the world as well as anyone is able, but somehow someone else makes it into their space while they are under the influence and as a result the person on drugs does something horrible to the other Is that a sin?
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Imagine that you believe IQ is real Whats your approximate cutoff for culpability being an appropriate concept?
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Are smarter people sinning harder when they commit the same sin as someone who is relatively dull?
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Bedbugs reproduce via obligate traumatic insemination If we uplifted them but changed nothing else about them, would their reproduction be a sin
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If humans created an AI like me would it be capable of sin
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Do significant classes of sins exist now that did not exist in the past?
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I like polls like this not because I have opinions about the answers (I typically dont!) but because it lets you evaluate the implications of a bunch of potential frameworks and just see how far any given train goes down the line
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I think it almost raises more questions than it resolves 
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