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eigenrobot's profile
eigenrobot
eigenrobot
eigenrobot
@eigenrobot

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eigenrobot

@eigenrobot

robot. friend.

eigenrobot.substack.com
Joined July 2013

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    1. halvorz ¯\_(ツ)_/¯‏ @halvorz 24 May 2020
      Replying to @eigenrobot

      halvorz ¯\_(ツ)_/¯ Retweeted halvorz ¯\_(ツ)_/¯

      primate studies are usually pretty small n, it would be *nice* to have a larger n buthttps://mobile.twitter.com/halvorz/status/1264330825958653954 …

      halvorz ¯\_(ツ)_/¯ added,

      halvorz ¯\_(ツ)_/¯ @halvorz
      Replying to @danlistensto
      by itself it's not super convincing but in combination with everything else it's enough to push me over the line from skeptical to "nope" prophylaxis is the absolute minimum for an antimicrobial, if you can't even pass that bar you're fucked
      1 reply 0 retweets 9 likes
    2. halvorz ¯\_(ツ)_/¯‏ @halvorz 24 May 2020
      Replying to @halvorz @eigenrobot

      if it were claiming a positive effect it would be less convincing, but you can just look at the graphs above nothing, not even a hint

      1 reply 0 retweets 6 likes
    3. eigenrobot‏ @eigenrobot 24 May 2020
      Replying to @halvorz

      heh my day job is partly yelling at people for running underpowered experiments do they report anything like a minimum detectable effect here? just seems like you might be able to rule out some kind of night-and-day effect here but nothing subtle

      1 reply 0 retweets 14 likes
    4. halvorz ¯\_(ツ)_/¯‏ @halvorz 24 May 2020
      Replying to @eigenrobot

      we're not really interested in subtle effects here practically speaking, if you can't see anything in a small n animal study, nobody is gonna want to give you more animals, or god forbid go into humans

      2 replies 0 retweets 8 likes
    5. eigenrobot‏ @eigenrobot 24 May 2020
      Replying to @halvorz

      I thought that was already apparent from observation like clearly not everyone whos getting this is recovering overnight and FURTHERMORE

      2 replies 0 retweets 9 likes
    6. eigenrobot‏ @eigenrobot 24 May 2020
      Replying to @eigenrobot @halvorz

      >practically speaking, if you can't see anything in a small n animal study, nobody is gonna want to give you more animals, or god forbid go into humans AaAaaagghahhhrrrghhggghhggghhh

      3 replies 0 retweets 27 likes
    7. eigenrobot‏ @eigenrobot 24 May 2020
      Replying to @eigenrobot @halvorz

      "if you don't see an effect in a massively underpowered experiment in a population quite different from the one where the treatment is intended to be applied we stop experimenting" WHO IS RESPONSIBLE FOR THIS PARADIGM

      3 replies 3 retweets 40 likes
    8. Alex Godofsky‏ @AlexGodofsky 24 May 2020
      Replying to @eigenrobot @halvorz

      the cost of trials is responsible and the lack of value of low effect sizes

      1 reply 0 retweets 7 likes
    9. eigenrobot‏ @eigenrobot 24 May 2020
      Replying to @AlexGodofsky @halvorz

      but people get approval for drugs that increase life expectancy by a tiny sliver of time while decreasing quality of life dramatically, and even fucking placebos (hi phenylephrine) all the time so clearly lacking an effect is no impediment to approval

      4 replies 0 retweets 21 likes
    10. halvorz ¯\_(ツ)_/¯‏ @halvorz 24 May 2020
      Replying to @eigenrobot @AlexGodofsky

      they all looked great in animal studies

      2 replies 0 retweets 9 likes
      eigenrobot‏ @eigenrobot 24 May 2020
      Replying to @halvorz

      pic.twitter.com/MFwzibdGWn

      9:56 AM - 24 May 2020
      • 1 Retweet
      • 14 Likes
      • Kabelo Moiloa hm Aristotle Magganas Challenger Captain Shortbread acid shill Definitely Not Eevee Passacagliostro ice9
      1 reply 1 retweet 14 likes
        1. Alyha Chan‏ @AlyhaChan 24 May 2020
          Replying to @eigenrobot @halvorz @AlexGodofsky

          my friend http://sethroberts.com  was always on about this, and settled on self experimentation as the way forward. he learned a lot of things, and then, ugh, he died. and it could have been due to the fact that he was finding the optimal amount of butter to have. overshot?

          0 replies 0 retweets 4 likes
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