primate studies are usually pretty small n, it would be *nice* to have a larger n buthttps://mobile.twitter.com/halvorz/status/1264330825958653954 …
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Replying to @halvorz @eigenrobot
if it were claiming a positive effect it would be less convincing, but you can just look at the graphs above nothing, not even a hint
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Replying to @halvorz
heh my day job is partly yelling at people for running underpowered experiments do they report anything like a minimum detectable effect here? just seems like you might be able to rule out some kind of night-and-day effect here but nothing subtle
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Replying to @eigenrobot
we're not really interested in subtle effects here practically speaking, if you can't see anything in a small n animal study, nobody is gonna want to give you more animals, or god forbid go into humans
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Replying to @halvorz
I thought that was already apparent from observation like clearly not everyone whos getting this is recovering overnight and FURTHERMORE
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Replying to @eigenrobot @halvorz
>practically speaking, if you can't see anything in a small n animal study, nobody is gonna want to give you more animals, or god forbid go into humans AaAaaagghahhhrrrghhggghhggghhh
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Replying to @eigenrobot @halvorz
"if you don't see an effect in a massively underpowered experiment in a population quite different from the one where the treatment is intended to be applied we stop experimenting" WHO IS RESPONSIBLE FOR THIS PARADIGM
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Replying to @eigenrobot @halvorz
the cost of trials is responsible and the lack of value of low effect sizes
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Replying to @AlexGodofsky @halvorz
but people get approval for drugs that increase life expectancy by a tiny sliver of time while decreasing quality of life dramatically, and even fucking placebos (hi phenylephrine) all the time so clearly lacking an effect is no impediment to approval
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Replying to @eigenrobot @AlexGodofsky
they all looked great in animal studies
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my friend http://sethroberts.com was always on about this, and settled on self experimentation as the way forward. he learned a lot of things, and then, ugh, he died. and it could have been due to the fact that he was finding the optimal amount of butter to have. overshot?
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