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eigenrobot

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eigenrobot.substack.com
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    1. halvorz ¯\_(ツ)_/¯‏ @halvorz 23 May 2020

      halvorz ¯\_(ツ)_/¯ Retweeted David R. Liu

      welp that settles it as far as I'm concerned absurd it took this long for someone to do monkey studies on thishttps://twitter.com/davidrliu/status/1263960572032430080 …

      halvorz ¯\_(ツ)_/¯ added,

      David R. Liu @davidrliu
      Can hydroxychloroquine prevent #SARSCoV2 infection if taken before exposure? Can it treat early or late #COVID19 infection, with or w/o azithromycin? This study in monkeys (prophylaxis n=5, treatment n=18 total, control n=8) concludes: no, no, no, & no. https://www.researchsquare.com/article/rs-27223/v1 … pic.twitter.com/HXGEJqIN9D
      Show this thread
      13 replies 12 retweets 69 likes
      eigenrobot‏ @eigenrobot 23 May 2020
      Replying to @halvorz

      does a study of this size, in another species, provide convincing evidence of anything in your field . . . usually?

      11:47 PM - 23 May 2020
      • 18 Likes
      • Songname His Honor Pazooki, Le Bweep of USA Aristotle Magganas dji ☠️ nnius 🇮🇲 Michael Keenan Mel Abusch, M.D. acid shill Definitely Not Eevee CUNII∞🌮FORM
      3 replies 0 retweets 18 likes
        1. New conversation
        2. halvorz ¯\_(ツ)_/¯‏ @halvorz 24 May 2020
          Replying to @eigenrobot

          halvorz ¯\_(ツ)_/¯ Retweeted halvorz ¯\_(ツ)_/¯

          primate studies are usually pretty small n, it would be *nice* to have a larger n buthttps://mobile.twitter.com/halvorz/status/1264330825958653954 …

          halvorz ¯\_(ツ)_/¯ added,

          halvorz ¯\_(ツ)_/¯ @halvorz
          Replying to @danlistensto
          by itself it's not super convincing but in combination with everything else it's enough to push me over the line from skeptical to "nope" prophylaxis is the absolute minimum for an antimicrobial, if you can't even pass that bar you're fucked
          1 reply 0 retweets 9 likes
        3. halvorz ¯\_(ツ)_/¯‏ @halvorz 24 May 2020
          Replying to @halvorz @eigenrobot

          if it were claiming a positive effect it would be less convincing, but you can just look at the graphs above nothing, not even a hint

          1 reply 0 retweets 6 likes
        4. Show replies
        1. New conversation
        2. Passacagliostro‏ @passacagliostro 24 May 2020
          Replying to @eigenrobot @halvorz

          [1/2] effect size should be large and variance small in studies when you can actually dose the monkeys with SARS-CoV-2 in a constant environment. my (extremely loose) rule of thumb is typically you will see same signal as human observational study w 100x size.

          1 reply 0 retweets 1 like
        3. Passacagliostro‏ @passacagliostro 24 May 2020
          Replying to @passacagliostro @eigenrobot @halvorz

          [2/2] For drugs that bind something in the human, efficacy translates poorly from primate models For drugs that bind something in the virus, efficacy translates pretty well but safety translates less well.

          1 reply 0 retweets 0 likes
        4. Show replies

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