welp that settles it as far as I'm concerned absurd it took this long for someone to do monkey studies on thishttps://twitter.com/davidrliu/status/1263960572032430080 …
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primate studies are usually pretty small n, it would be *nice* to have a larger n buthttps://mobile.twitter.com/halvorz/status/1264330825958653954 …
if it were claiming a positive effect it would be less convincing, but you can just look at the graphs above nothing, not even a hint
[1/2] effect size should be large and variance small in studies when you can actually dose the monkeys with SARS-CoV-2 in a constant environment. my (extremely loose) rule of thumb is typically you will see same signal as human observational study w 100x size.
[2/2] For drugs that bind something in the human, efficacy translates poorly from primate models For drugs that bind something in the virus, efficacy translates pretty well but safety translates less well.
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