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eigenrobot's profile
eigenrobot
eigenrobot
eigenrobot
@eigenrobot

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eigenrobot

@eigenrobot

robot. friend.

eigenrobot.substack.com
Joined July 2013

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    1. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      basically: all this is super speculative at this point, so i don't think there's enough evidence to argue in favor or against doing serotonergics, beyond "mental health is important during lockdowns"

      1 reply 0 retweets 3 likes
    2. Sarah McManus‏ @SarahAMcManus 19 Mar 2020
      Replying to @FioraAeterna @dispirateparts

      Very much appreciating the data & analysis! 💊💖📄👩‍🔬🤓💪

      1 reply 0 retweets 2 likes
    3. Sarah McManus‏ @SarahAMcManus 19 Mar 2020
      Replying to @SarahAMcManus @FioraAeterna @dispirateparts

      I've been wondering about TNF alpha immunosuppressants and COVID-19! A close friend is on Humira - in fact she's on a large group video call about Crohn's and coronavirus right now. Any links about the potential effects there?

      2 replies 0 retweets 7 likes
    4. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @SarahAMcManus @dispirateparts

      so this is actually super fascinating to me, and i can go into a bit more detail of what i know (as speculative as it is): it SEEMS like prognosis for COVID-19 is all about your ability to produce and maintain killer T-cells to go around killing cells that are virus-infected.

      1 reply 0 retweets 1 like
    5. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      people who run low on T cells tend to have a very poor prognosis, and adaptive immune system function is highly correlated with success in fighting off COVID-19. this matches the age relationship, because thymus function massively declines with age (see thymic involution).

      1 reply 0 retweets 1 like
    6. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      now, to get into more speculative territory: why are the T-cells running out? if i understand things correctly: there are signalling pathways that trigger T-cell apoptosis. they largely exist to prevent the T-cells from mass-targetting healthy tissue by mistake.

      1 reply 0 retweets 1 like
    7. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      it's possible that the virus is doing something in order to try to trigger or enhance this pathway. it's also possible that it's simply a matter of how much progress the virus makes before the T-cells really get started, and if the virus is too far ahead, they're just doomed.

      1 reply 0 retweets 1 like
    8. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      AFAIK, the TNF-alpha pathway *is the pathway that suppresses T-cells like this*. so arguably, it might actually be BENEFICIAL to suppress TNF alpha, in order to enhance adaptive immune system function.

      1 reply 0 retweets 2 likes
    9. Fiora‏ @FioraAeterna 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      anecdotally, i have heard stories of people taking sub-psychedelic doses of DOI for its TNF alpha suppression properties, as a poor man's Humira substitute (it's a picomolar, yes, picomolar TNF alpha suppressor http://jpet.aspetjournals.org/content/327/2/316 …)

      2 replies 0 retweets 3 likes
    10. bosco‏ @selentelechia 19 Mar 2020
      Replying to @FioraAeterna @SarahAMcManus @dispirateparts

      woah holy shit @eigenrobot

      1 reply 0 retweets 2 likes
      eigenrobot‏ @eigenrobot 19 Mar 2020
      Replying to @selentelechia @FioraAeterna and

      Huh Nice

      5:06 PM - 19 Mar 2020
      • 3 Likes
      • bosco Raymond
      0 replies 0 retweets 3 likes

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