genomics question 1. there are huge numbers of SNPs thats tricky 2. there are 23 or so chromosomes 3. roughly, chromosomes can change by mutation or by recombination 4. recombination is relatively infrequent for adjacent sequences 5. mutation is relatively infrequent
-
Show this thread
-
so A. seems like within a population there will probably a relatively (compared to SNPs especially) small number of consistently-appearing longer segments across generations, especially if some loci are quite a lot more likely to be the site of crossing over than others?
1 reply 0 retweets 5 likesShow this thread -
B. if you can identify these groups you might have a better time using them as features (vs SNPs) especially given eg role of introns in the regulation of expression?
2 replies 0 retweets 2 likesShow this thread -
C. Seems like you could deduce the traits of (successful) founders of populations from these traits a la linguistic archaeology?
4 replies 0 retweets 6 likesShow this thread -
I have no idea what I'm talking about
2 replies 1 retweet 15 likesShow this thread -
eigenrobot Retweeted Arguably Wrong
OHOHOHOHO looks like ive just reinvented something (badly) again just like that time i worked myself up to reinventing shitty cryptographic hashes someday its gonna be something Newhttps://twitter.com/arguablywrong/status/1202803515782914048?s=19 …
eigenrobot added,
2 replies 0 retweets 18 likesShow this thread -
Replying to @eigenrobot
yeah when you were talking about simulating offspring the other day I was wondering about phasing but then I saw that 23andMe can phase your data if you have family members in their database so I assumed you had that data
2 replies 0 retweets 1 like -
Replying to @halvorz @eigenrobot
see also: https://en.wikipedia.org/wiki/Identity_by_descent … which is how this sweet fig was madepic.twitter.com/YcaMHZGXYJ
1 reply 0 retweets 1 like -
Replying to @halvorz
Oh man that software section is sexy I really am coming at this fairly naive, haven't take a bio class since 2007(?) and uh things seem to have Progressed
1 reply 0 retweets 2 likes -
do you have a link to the 23andMe phasing deets? Trying to figure out the easiest way of managing this for @selentelechia, wonder if going with her paternal grandpatents would suffice in place of her bio dad
-
-
Nm found it!
0 replies 0 retweets 2 likesThanks. Twitter will use this to make your timeline better. UndoUndo
-
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.