genomics question 1. there are huge numbers of SNPs thats tricky 2. there are 23 or so chromosomes 3. roughly, chromosomes can change by mutation or by recombination 4. recombination is relatively infrequent for adjacent sequences 5. mutation is relatively infrequent
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so A. seems like within a population there will probably a relatively (compared to SNPs especially) small number of consistently-appearing longer segments across generations, especially if some loci are quite a lot more likely to be the site of crossing over than others?
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B. if you can identify these groups you might have a better time using them as features (vs SNPs) especially given eg role of introns in the regulation of expression?
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C. Seems like you could deduce the traits of (successful) founders of populations from these traits a la linguistic archaeology?
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I have no idea what I'm talking about
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eigenrobot Retweeted Arguably Wrong
OHOHOHOHO looks like ive just reinvented something (badly) again just like that time i worked myself up to reinventing shitty cryptographic hashes someday its gonna be something Newhttps://twitter.com/arguablywrong/status/1202803515782914048?s=19 …
eigenrobot added,
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Replying to @eigenrobot
yeah when you were talking about simulating offspring the other day I was wondering about phasing but then I saw that 23andMe can phase your data if you have family members in their database so I assumed you had that data
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Replying to @halvorz
no kids tho
maybe I get my folks kits but that doesnt exactly solve the problem
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@selentelechia ps wanna get your mom a kit how about some folks on your dads side
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Funny thing about inheritance: each kid is always 50% mom and 50% dad, barring a huge defect or mutation. But almost nobody is 25% each grandparent. You inherit their genes basically at random from your parents.
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