genomics question 1. there are huge numbers of SNPs thats tricky 2. there are 23 or so chromosomes 3. roughly, chromosomes can change by mutation or by recombination 4. recombination is relatively infrequent for adjacent sequences 5. mutation is relatively infrequent
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so A. seems like within a population there will probably a relatively (compared to SNPs especially) small number of consistently-appearing longer segments across generations, especially if some loci are quite a lot more likely to be the site of crossing over than others?
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B. if you can identify these groups you might have a better time using them as features (vs SNPs) especially given eg role of introns in the regulation of expression?
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Replying to @eigenrobot
Genes aren't everything in expression. Environment also affects expression so that could throw whatever you're aiming at.
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Replying to @eigenrobot
Have you seen this series? https://www.youtube.com/watch?v=NNnIGh9g6fA …
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Replying to @a_thing_to_do
hmmm have not video is hard for me spose i have a strong biochemistry undergrad degree but haven't used it for a decade how much will i learn
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Replying to @eigenrobot
I only have 2 years Biotech grad under me and I found it interesting. But that was mainly because I never really cared about macro applications of what I was learning (esp re:society ect). So for me was a nice eye opener but yeah a few chunks of are real basic.
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Huuh ok may podcast it at some point maybe?
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