well
fuck
looks like between chip v2 and chip v5 @23andMe altered their nomenclature such that there's only an intersection of about 20% of rsids across chips
hmmm
-
Show this thread
-
possibilities: 1.
@23andMe are just legitimately measuring a completely different set of SNPs today (why would they do this? FDA mandate?) 2. its is actually a nomenclature shift per above tweet, iirc theres variation in naming conventions but havent thought about this in years4 replies 1 retweet 5 likesShow this thread -
eigenrobot Retweeted PoliMath
yeah ok might not be fda mandated either, as I think about it quite likely the v2 SNP set was relatively badly(?) curated compared to the v5 and/or they just changed suppliershttps://twitter.com/politicalmath/status/1202133010658709504 …
eigenrobot added,
2 replies 0 retweets 1 likeShow this thread -
note that there are many millions of mapped SNPs so its p plausible they (slash their suppliers--always a Genome Reference Consortium product?) just shifted their collection as different SNPs drifted in and out of popularity v5 chips based on this fella https://www.ncbi.nlm.nih.gov/grc/human
1 reply 0 retweets 1 likeShow this thread -
AHA per
@politicalmath , they HAVE changed suppliers and those suppliers DO measure a very different set of SNPspic.twitter.com/v88pVFkaQF
1 reply 1 retweet 3 likesShow this thread -
well now im cranky modeling is going to be a pain in the ass and i need to learn more about it before i make any decisions probably the easiest way forward is to get a v5/GSA sequence so my rsids match are a superset of
@selentelechia's, but this limits generalizability1 reply 0 retweets 3 likesShow this thread -
I guess the obvious thing to do is just reproduce the entire existing literature so i can build my own tools
2 replies 0 retweets 8 likesShow this thread -
well ok gonna call it but be grateful for feedback before I blow any cash on a 23andMe upgrade seems like the other obvious option is veritas if I can get the raw data analysis would prolly be much harder there tho 140gb, maybe gotta get a few more RAM sticks . . .
3 replies 0 retweets 2 likesShow this thread -
any recommendations for amateur genomics resources?
2 replies 0 retweets 1 likeShow this thread -
Replying to @eigenrobot
I missed original questions, but if male, BigY from FTDNA is really interesting.
1 reply 0 retweets 2 likes
will investigate, thank you!
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.