ok finished working for the day time to write a script to generate several thousand children
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note that there are many millions of mapped SNPs so its p plausible they (slash their suppliers--always a Genome Reference Consortium product?) just shifted their collection as different SNPs drifted in and out of popularity v5 chips based on this fella https://www.ncbi.nlm.nih.gov/grc/human
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AHA per
@politicalmath , they HAVE changed suppliers and those suppliers DO measure a very different set of SNPspic.twitter.com/v88pVFkaQF
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well now im cranky modeling is going to be a pain in the ass and i need to learn more about it before i make any decisions probably the easiest way forward is to get a v5/GSA sequence so my rsids match are a superset of
@selentelechia's, but this limits generalizabilityShow this thread -
I guess the obvious thing to do is just reproduce the entire existing literature so i can build my own tools
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well ok gonna call it but be grateful for feedback before I blow any cash on a 23andMe upgrade seems like the other obvious option is veritas if I can get the raw data analysis would prolly be much harder there tho 140gb, maybe gotta get a few more RAM sticks . . .
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I don't think they changed suppliers, Illumina has supplied 23andMe with sequencers for a loooong time. But! There was an Illumina update in v5 that might have something to do with thishttps://www.xcode.life/23andme/23andme-v5-chip-dna-raw-data-analysis/ …
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