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Found a quite interesting paper on evolution, aging, and mice as a biomedical test model: https://www.sciencedirect.com/science/article/pii/S0531556502000128?via%3Dihub … from an also interesting (long) podcast episode:https://www.stitcher.com/podcast/kast-media-2/the-portal-2/e/66665404 …
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Michael Levin Retweeted
Permanently 2-headed planaria, being themselves. Footage by Junji Morokuma in the Levin lab, music by Edvard Grieg.pic.twitter.com/cn6zzf1zAv
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Here's one of the long-form essays on Causation in biology expanding on https://www.nature.com/articles/s41580-019-0127-1 …: "Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation": https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201900146 … Others' (like
@yoginho's) should be out soon in forthcoming collection.pic.twitter.com/e2dKaqWvw9
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What model systems’ embryos are easily dissociated into cells? Chemical method, ideally (not manual dissection), and we want the cells to stay alive (not for fixation). Can zebrafish? C. elegans? Other invertebrates? The weirder the better. Ideas?
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Rubber Hand Illusion https://www.youtube.com/watch?v=TCQbygjG0RU … & more generally https://en.wikipedia.org/wiki/Body_transfer_illusion … Isn't it weird that despite long evolutionary time of dependable (constant) body structure, brain is willing to abandon default, & revise somatic self-model after mere ~20 minutes of experience?
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This is quite useful: "The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators." https://thenode.biologists.com/network/
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Very interesting collection: "Evolution, Development and Complexity: Multiscale Evolutionary Models of Complex Adaptive Systems"https://www.springer.com/gp/book/9783030000745 …
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Final version of methods paper on workflow for quantifying calcium/bioelectricity tracking in frog embryos, by Patrick McMillen (from our lab) and Richard Novak, a great collaborator and scientist at
@wyssinstitute :https://authors.elsevier.com/a/1aU2954HFDeiEThanks. Twitter will use this to make your timeline better. UndoUndo -
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Lots to think about here: https://www.ncbi.nlm.nih.gov/pubmed/18406536 "The neuron-level phenomena underlying cognition and consciousness: synaptic activity and the action potential."
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Before very important Jan. event, told myself "no thinking about new directions until all prep is done & we get past it." Oddly, this triggered flood of new ideas (written down for later). Is this a known thing? What strategies do you all use for enhancing actionable creativity?pic.twitter.com/zKkejF932T
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There are molecular/physiological markers of stress, both on cellular level and organismal level. Are there markers of happiness? Is there anything that can be assayed to detect when a cell/tissue/organ is within optimal allostatic point (opposite of stressed)?
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A very nice tutorial chapter on gene networks processing positional information: https://www.ncbi.nlm.nih.gov/pubmed/30324604 "Modelling Time-Dependent Acquisition of Positional Information."
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"Living matter is the repetitive production of ordered heterogeneity." – Rollin Hotchkiss, 1958pic.twitter.com/c6eblIamjh
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More info here: https://cdorgs.github.io/ This is just the beginning - stay tuned later this year; these critters have *amazing* behavior.
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Check out our (
@DoctorJosh,@Kriegmerica, Doug Blackiston) latest in PNAS: https://www.pnas.org/content/early/2020/01/07/1910837117 … 1st of a series of papers on new synthetic living machines. What kinds of bodies can frog cells (no genomic editing) make when liberated from the embryo? Guided self-assembly.pic.twitter.com/OccH7rVyaw
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Some really interesting work on cell:cell competition in vivo: https://www.nature.com/articles/s41586-019-1429-3.pdf … https://www.ncbi.nlm.nih.gov/pubmed/30208354 https://www.ncbi.nlm.nih.gov/pubmed/27319281 https://www.ncbi.nlm.nih.gov/pubmed/27066183 https://www.ncbi.nlm.nih.gov/pubmed/25754635 https://www.ncbi.nlm.nih.gov/pubmed/26631518 http://www.ncbi.nlm.nih.gov/pubmed/21239349 http://www.ncbi.nlm.nih.gov/pubmed/20627080
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Does biology have truly difficult ideas? Studying math, comp sci, physics, etc., one quickly encounters material that is hard to truly grasp (and many of us get to a point where we mentally just can't go further, while some others can). Does this exist in biology? If not, why?pic.twitter.com/XFGnSfP2df
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In the spirit of https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005268 … I ask folks who infer gene regulatory networks: has anyone tried 1) create a synthetic (cell free?) set of transcription factors, 2) profile gene levels, 3) reconstruct GRN - does the result look anything like circuit that's really there?
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Re. deep net models that get answers right without explaining what's inside the black box. Isn't this what quantum physicists say - QM theory is great because it gives right answers to huge precision, and that asking for an understandable picture of what's inside is misguided?pic.twitter.com/dBCmyOHTiX
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