There is a buttload (real unit of measure, look it up) of work on how ant. cingulate cortex regions contribute to decisions involving reward uncertainty in both humans and animals. Thing is, some say it makes you more risky…pic.twitter.com/SamoMLtvVs
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One issue is that human assays often use external cues to inform decision makers about the likelihoods of receiving rewards, whereas most animal task require use of internal representation of reward historypic.twitter.com/L0Sb1IH3h1
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So, we used an assay we call the “Blackjack” task (admittedly, in part, for marketing purposes), where rats choose between small/certain vs larger/risky (uncertain) rewards. Each trial, different sound cues inform the odds of getting a bigger payoff are either good or poor.pic.twitter.com/HqsJuFaDbj
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Using ol’ school pharmacology, we targeted the ventral infralimbic, or more dorsal prelimbic or anterior cingulate cortex (ACC) in rats that were experienced playerspic.twitter.com/6O33dGaUbD
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We found that shutting down ventral PFC made rats play more risky, on poor-odds trials (when they SHOULD have been selecting the smaller/certain option more)pic.twitter.com/09jMkm2QdZ
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On the other hand, inactivating either dorsal region made rats play more risky averse on good-odds trials (when they’d be better served to play more risky)pic.twitter.com/vcoXfk5lbN
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But THEN,
@miekevholstein dug deeper to try parse if there were any additional differences between the prelimbic vs dorsal ACC. Turns out, prelimbic inactivation made rats less sensitive to rewarded choicespic.twitter.com/GPZC3sitdwPrikaži ovu nit -
In contrast, when we shut down ACC, rats were more sensitive to non-rewarded choicespic.twitter.com/mOjY2yBMZ2
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Importantly, none of these treatments affected the ability to use these cues to guide choice on a simpler discrimination when rewards were delivered deterministicallypic.twitter.com/s0YQGmGOlV
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So, both dorsal vs ventral PFC regions promote more optimal cue-guided, risk/reward decision making, either promoting good risky choices or vs inhibiting less profitable onespic.twitter.com/Irs9Q6bCPa
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What’s more, we think these data may help parse out how different regions of the dorsal anterior cingulate in humans may differentially guide these types of decisionspic.twitter.com/09q37tUvGv
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So, after 3 years, 5 reviewers and 2 different journals, we are happy to move on to our next adventures! Thanks for listening!pic.twitter.com/n9c3m1Y8i0
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