exactly why mitoDNA ought to be sequestered from the mitochondria itself, though.
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Right, but how the hell are you gonna do that? It's basically trying to make a genome-free bacteria, that still replicates itself.
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The rest of the organelles are made via nuclear template, I don't see an a priori reason why the mitochondria can't be as well. This might call for engineering at a level of subtlety we're not capable of, yet. Or maybe the ribosome will just build it given RNA
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The other organelles have a wildly different origin and wildly different basic architecture. Mitochondria are just highly modified bacteria. In principle you could build it from scratch, but, yes, it would require engineering at a level we can't even conceive of yet.
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All of those things are true but nonetheless, the mitochondrion sends RNA to the ribosome just like the nucleus does. It's not 100% clear that moving the DNA to the nucleus would disrupt anything. I'm glad the experiments are being done.
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No, it doesn't. Mitochondria code for their own ribosomes, which are extremely different from nuclear ribosomes.
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Mitochondria *contain* their own ribosomes. Are their codons in the 13 mitochondrial genes, or the more than 1000 which have already migrated to the nucleus?
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it does seem vanishingly unlikely that it would transport only the correct RNA across its membrane, and that the cytosomal ribosome would ignore it. So, okay, hard problem.
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The ribosomal RNAs are transcribed from mitochondrial DNA, the ribosomal proteins are encoded in nuclear DNA.
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"in vertebrates, all mitochondrial ribosomal proteins are coded and synthesised outside the organelle." cit. https://www.sciencedirect.com/science/article/pii/S0005272898001613 …
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The difference in codon interpretation is exciting because it may mean that, say, prepending a stop codon right after the primer might cause an extra tryptophan in the mitochondrion but prevent transcription in the cytosome.
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