https://www.sens.org/research/introduction-to-sens-research/mitochondrial-mutations … rejiggering mtDNA locations is an active project for at least one org, though they have an Interesting approach.
it does seem vanishingly unlikely that it would transport only the correct RNA across its membrane, and that the cytosomal ribosome would ignore it. So, okay, hard problem.
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The ribosomal RNAs are transcribed from mitochondrial DNA, the ribosomal proteins are encoded in nuclear DNA.
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"in vertebrates, all mitochondrial ribosomal proteins are coded and synthesised outside the organelle." cit. https://www.sciencedirect.com/science/article/pii/S0005272898001613 …
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The difference in codon interpretation is exciting because it may mean that, say, prepending a stop codon right after the primer might cause an extra tryptophan in the mitochondrion but prevent transcription in the cytosome.
End of conversation
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