-
-
Replying to @AmbrosialArts @djinnius and
doesn't actually replace the mtDNA but rather does the opposite thing of replacing the DNA, but, gimme a sec....
2 replies 0 retweets 4 likes -
Replying to @AmbrosialArts @djinnius and
https://www.sens.org/research/introduction-to-sens-research/mitochondrial-mutations … rejiggering mtDNA locations is an active project for at least one org, though they have an Interesting approach.
1 reply 0 retweets 3 likes -
It's fairly astonishing how quickly this is developing. We may have mammals with a single printed chromosome and no mitochondria in a matter of years.
2 replies 0 retweets 1 like -
I really don't think we'll be able to do away with mitochondria like, ever. There are serious functional constraints. We sequester the metabolic stuff they do for very good reason, you get a lot of nasty radicals which we don't want damaging our DNA.
1 reply 0 retweets 2 likes -
exactly why mitoDNA ought to be sequestered from the mitochondria itself, though.
1 reply 0 retweets 2 likes -
Right, but how the hell are you gonna do that? It's basically trying to make a genome-free bacteria, that still replicates itself.
1 reply 0 retweets 1 like -
The rest of the organelles are made via nuclear template, I don't see an a priori reason why the mitochondria can't be as well. This might call for engineering at a level of subtlety we're not capable of, yet. Or maybe the ribosome will just build it given RNA
1 reply 0 retweets 1 like -
The other organelles have a wildly different origin and wildly different basic architecture. Mitochondria are just highly modified bacteria. In principle you could build it from scratch, but, yes, it would require engineering at a level we can't even conceive of yet.
1 reply 0 retweets 1 like -
All of those things are true but nonetheless, the mitochondrion sends RNA to the ribosome just like the nucleus does. It's not 100% clear that moving the DNA to the nucleus would disrupt anything. I'm glad the experiments are being done.
2 replies 0 retweets 1 like
I mean it seems likely. Maybe the remaining genes just didn't random-walk over to the nucleus, or maybe there's some reason they have to live in the mitochondria. One way to find out
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.