'closely related' is relative, mitochondrial DNA is fairly conservative Replacing mitochondrial DNA might be possible but afaik hasn't been accomplished to date
The rest of the organelles are made via nuclear template, I don't see an a priori reason why the mitochondria can't be as well. This might call for engineering at a level of subtlety we're not capable of, yet. Or maybe the ribosome will just build it given RNA
-
-
The other organelles have a wildly different origin and wildly different basic architecture. Mitochondria are just highly modified bacteria. In principle you could build it from scratch, but, yes, it would require engineering at a level we can't even conceive of yet.
-
All of those things are true but nonetheless, the mitochondrion sends RNA to the ribosome just like the nucleus does. It's not 100% clear that moving the DNA to the nucleus would disrupt anything. I'm glad the experiments are being done.
-
No, it doesn't. Mitochondria code for their own ribosomes, which are extremely different from nuclear ribosomes.
-
Mitochondria *contain* their own ribosomes. Are their codons in the 13 mitochondrial genes, or the more than 1000 which have already migrated to the nucleus?
-
it does seem vanishingly unlikely that it would transport only the correct RNA across its membrane, and that the cytosomal ribosome would ignore it. So, okay, hard problem.
-
The ribosomal RNAs are transcribed from mitochondrial DNA, the ribosomal proteins are encoded in nuclear DNA.
-
"in vertebrates, all mitochondrial ribosomal proteins are coded and synthesised outside the organelle." cit. https://www.sciencedirect.com/science/article/pii/S0005272898001613 …
-
The difference in codon interpretation is exciting because it may mean that, say, prepending a stop codon right after the primer might cause an extra tryptophan in the mitochondrion but prevent transcription in the cytosome.
End of conversation
New conversation -
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.