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djinnius's profile
sam atman
sam atman
sam atman
@djinnius

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sam atman

@djinnius

Philosopher of letters. Math nut. Wizard. ~wep

back into lunar orbit
github.com/mnemnion
Joined March 2009

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    1. sam atman‏ @djinnius Sep 14
      Replying to @browserdotsys @halvorz

      'closely related' is relative, mitochondrial DNA is fairly conservative Replacing mitochondrial DNA might be possible but afaik hasn't been accomplished to date

      2 replies 0 retweets 4 likes
    2. Dolores  🏴 ✨‏ @AmbrosialArts Sep 14
      Replying to @djinnius @browserdotsys @halvorz

      https://www.npr.org/sections/health-shots/2018/06/06/616334508/her-son-is-one-of-the-few-children-to-have-3-parents …

      1 reply 0 retweets 6 likes
    3. Dolores  🏴 ✨‏ @AmbrosialArts Sep 14
      Replying to @AmbrosialArts @djinnius and

      doesn't actually replace the mtDNA but rather does the opposite thing of replacing the DNA, but, gimme a sec....

      2 replies 0 retweets 4 likes
    4. Dolores  🏴 ✨‏ @AmbrosialArts Sep 14
      Replying to @AmbrosialArts @djinnius and

      https://www.sens.org/research/introduction-to-sens-research/mitochondrial-mutations … rejiggering mtDNA locations is an active project for at least one org, though they have an Interesting approach.

      1 reply 0 retweets 3 likes
    5. sam atman‏ @djinnius Sep 14
      Replying to @AmbrosialArts @browserdotsys @halvorz

      It's fairly astonishing how quickly this is developing. We may have mammals with a single printed chromosome and no mitochondria in a matter of years.

      2 replies 0 retweets 1 like
    6. halvorz‏ @halvorz Sep 14
      Replying to @djinnius @AmbrosialArts @browserdotsys

      I really don't think we'll be able to do away with mitochondria like, ever. There are serious functional constraints. We sequester the metabolic stuff they do for very good reason, you get a lot of nasty radicals which we don't want damaging our DNA.

      1 reply 0 retweets 2 likes
    7. Dolores  🏴 ✨‏ @AmbrosialArts Sep 14
      Replying to @halvorz @djinnius @browserdotsys

      exactly why mitoDNA ought to be sequestered from the mitochondria itself, though.

      1 reply 0 retweets 2 likes
    8. halvorz‏ @halvorz Sep 14
      Replying to @AmbrosialArts @djinnius @browserdotsys

      Right, but how the hell are you gonna do that? It's basically trying to make a genome-free bacteria, that still replicates itself.

      1 reply 0 retweets 1 like
      sam atman‏ @djinnius Sep 14
      Replying to @halvorz @AmbrosialArts @browserdotsys

      The rest of the organelles are made via nuclear template, I don't see an a priori reason why the mitochondria can't be as well. This might call for engineering at a level of subtlety we're not capable of, yet. Or maybe the ribosome will just build it given RNA

      2:09 PM - 14 Sep 2018
      1 reply 0 retweets 1 like
        1. New conversation
        2. halvorz‏ @halvorz Sep 14
          Replying to @djinnius @AmbrosialArts @browserdotsys

          The other organelles have a wildly different origin and wildly different basic architecture. Mitochondria are just highly modified bacteria. In principle you could build it from scratch, but, yes, it would require engineering at a level we can't even conceive of yet.

          1 reply 0 retweets 1 like
        3. sam atman‏ @djinnius Sep 14
          Replying to @halvorz @AmbrosialArts @browserdotsys

          All of those things are true but nonetheless, the mitochondrion sends RNA to the ribosome just like the nucleus does. It's not 100% clear that moving the DNA to the nucleus would disrupt anything. I'm glad the experiments are being done.

          2 replies 0 retweets 1 like
        4. halvorz‏ @halvorz Sep 14
          Replying to @djinnius @AmbrosialArts @browserdotsys

          No, it doesn't. Mitochondria code for their own ribosomes, which are extremely different from nuclear ribosomes.

          1 reply 0 retweets 0 likes
        5. sam atman‏ @djinnius Sep 15
          Replying to @halvorz @AmbrosialArts @browserdotsys

          Mitochondria *contain* their own ribosomes. Are their codons in the 13 mitochondrial genes, or the more than 1000 which have already migrated to the nucleus?

          1 reply 0 retweets 1 like
        6. sam atman‏ @djinnius Sep 15
          Replying to @djinnius @halvorz and

          it does seem vanishingly unlikely that it would transport only the correct RNA across its membrane, and that the cytosomal ribosome would ignore it. So, okay, hard problem.

          1 reply 0 retweets 1 like
        7. halvorz‏ @halvorz Sep 15
          Replying to @djinnius @AmbrosialArts @browserdotsys

          The ribosomal RNAs are transcribed from mitochondrial DNA, the ribosomal proteins are encoded in nuclear DNA.

          1 reply 0 retweets 2 likes
        8. sam atman‏ @djinnius Sep 15
          Replying to @halvorz @AmbrosialArts @browserdotsys

          "in vertebrates, all mitochondrial ribosomal proteins are coded and synthesised outside the organelle." cit. https://www.sciencedirect.com/science/article/pii/S0005272898001613 …

          2 replies 0 retweets 1 like
        9. sam atman‏ @djinnius Sep 15
          Replying to @djinnius @halvorz and

          The difference in codon interpretation is exciting because it may mean that, say, prepending a stop codon right after the primer might cause an extra tryptophan in the mitochondrion but prevent transcription in the cytosome.

          0 replies 0 retweets 1 like
        10. End of conversation

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