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djinnius's profile
sam atman
sam atman
sam atman
@djinnius

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sam atman

@djinnius

Philosopher of letters. Math nut. Wizard. ~wep

back into lunar orbit
github.com/mnemnion
Joined March 2009

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    1. sam atman‏ @djinnius Sep 14
      Replying to @browserdotsys @halvorz

      'closely related' is relative, mitochondrial DNA is fairly conservative Replacing mitochondrial DNA might be possible but afaik hasn't been accomplished to date

      2 replies 0 retweets 4 likes
    2. Dolores  🏴 ✨‏ @AmbrosialArts Sep 14
      Replying to @djinnius @browserdotsys @halvorz

      https://www.npr.org/sections/health-shots/2018/06/06/616334508/her-son-is-one-of-the-few-children-to-have-3-parents …

      1 reply 0 retweets 6 likes
    3. Dolores  🏴 ✨‏ @AmbrosialArts Sep 14
      Replying to @AmbrosialArts @djinnius and

      doesn't actually replace the mtDNA but rather does the opposite thing of replacing the DNA, but, gimme a sec....

      2 replies 0 retweets 4 likes
    4. sam atman‏ @djinnius Sep 14
      Replying to @AmbrosialArts @browserdotsys @halvorz

      Yep. Printing a full wooly mammoth genome is the hard part. Inserting it into an elephant egg is tractable now and would probably work.

      1 reply 0 retweets 5 likes
    5. halvorz‏ @halvorz Sep 14
      Replying to @djinnius @AmbrosialArts @browserdotsys

      As far as I know nobody is anywhere near doing whole genome transplantation in mammalian cells. Significant technological advances required there. It'll be hard enough to avoid simply physically breaking the DNA, and getting it into cells is...¯\_(ツ)_/¯

      1 reply 0 retweets 1 like
      sam atman‏ @djinnius Sep 14
      Replying to @halvorz @AmbrosialArts @browserdotsys

      The three parents article is about whole genome transplantation in mammalian (human) cells. You use a needle. nbd.

      2:05 PM - 14 Sep 2018
      1 reply 0 retweets 1 like
        1. New conversation
        2. halvorz‏ @halvorz Sep 14
          Replying to @djinnius @AmbrosialArts @browserdotsys

          That's nuclear transplantation, which is pretty ho-hum, yes. Been done with mammalian cells since Dolly, and with others even earlier. Naked DNA is a completely different ballgame.

          1 reply 0 retweets 2 likes
        3. sam atman‏ @djinnius Sep 14
          Replying to @halvorz @AmbrosialArts @browserdotsys

          A company I used to work for is developing, with fair success, a nanoparticle encapsulation of DNA. This can be injected into the cell and gets pulled into the nucleus via GCPR, which unravels it. Different ballgame, yes. We are *so* close though.

          1 reply 0 retweets 2 likes
        4. halvorz‏ @halvorz Sep 14
          Replying to @djinnius @AmbrosialArts @browserdotsys

          I would be very surprised if their nanoparticles were capable of encapsulating whole chromosomes. Lot of nanoparticle delivery systems out there, but nobody (except Craig Venter maybe) is trying to deliver whole chromosomes.

          1 reply 0 retweets 0 likes
        5. sam atman‏ @djinnius Sep 15
          Replying to @halvorz @AmbrosialArts @browserdotsys

          I suggest reading the other paper on the single-chromosome yeast. They CRISPR (basically) all the yeast chromosomes together while deleting a bunch of centromeres and telomeres. The same technique can be used to assemble a chromosome from smaller DNA fragments.

          1 reply 0 retweets 1 like
        6. halvorz‏ @halvorz Sep 15
          Replying to @djinnius @AmbrosialArts @browserdotsys

          It's an interesting idea, but the problem here is scale. Eukaryotic genomes are generally *massive* (though yeast is a notable exception). Getting 3 billion bp of DNA into a single cell is gonna be really, really hard.

          1 reply 0 retweets 1 like
        7. halvorz‏ @halvorz Sep 15
          Replying to @halvorz @djinnius and

          Though there's an interesting convergence here with another conversation I was having yesterday, on the feasibility of making, say, a mouse (or human) 'minimal genome.'

          1 reply 0 retweets 1 like
        8. halvorz‏ @halvorz Sep 15
          Replying to @halvorz @djinnius and

          It's likely that 70-90% of the human genome is non-functional, so if you could strip that out, the problem becomes somewhat simpler.

          1 reply 0 retweets 1 like
        9. sam atman‏ @djinnius Sep 15
          Replying to @halvorz @AmbrosialArts @browserdotsys

          Yes. This conversation has convinced me that removing mitochondria outright may be, er, a challenge. I still think we'll have a single-chromosome, printed mammal in five years or less.

          1 reply 0 retweets 2 likes
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