'closely related' is relative, mitochondrial DNA is fairly conservative Replacing mitochondrial DNA might be possible but afaik hasn't been accomplished to date
The first part has been done with yeast already, there's no real barrier to a mouse model at this pointhttps://www.nature.com/articles/s41586-018-0382-x …
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Yeast genome is tiny relative to mammalian genomes, suspect would run into segregation problems if tried to make multi-gigabase chromosomes in mammals. Tbf tulip chromosomes are already there, but plants are weird.
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