'closely related' is relative, mitochondrial DNA is fairly conservative Replacing mitochondrial DNA might be possible but afaik hasn't been accomplished to date
It's fairly astonishing how quickly this is developing. We may have mammals with a single printed chromosome and no mitochondria in a matter of years.
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I really don't think we'll be able to do away with mitochondria like, ever. There are serious functional constraints. We sequester the metabolic stuff they do for very good reason, you get a lot of nasty radicals which we don't want damaging our DNA.
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exactly why mitoDNA ought to be sequestered from the mitochondria itself, though.
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Right, but how the hell are you gonna do that? It's basically trying to make a genome-free bacteria, that still replicates itself.
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The rest of the organelles are made via nuclear template, I don't see an a priori reason why the mitochondria can't be as well. This might call for engineering at a level of subtlety we're not capable of, yet. Or maybe the ribosome will just build it given RNA
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The other organelles have a wildly different origin and wildly different basic architecture. Mitochondria are just highly modified bacteria. In principle you could build it from scratch, but, yes, it would require engineering at a level we can't even conceive of yet.
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All of those things are true but nonetheless, the mitochondrion sends RNA to the ribosome just like the nucleus does. It's not 100% clear that moving the DNA to the nucleus would disrupt anything. I'm glad the experiments are being done.
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No, it doesn't. Mitochondria code for their own ribosomes, which are extremely different from nuclear ribosomes.
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Mitochondria *contain* their own ribosomes. Are their codons in the 13 mitochondrial genes, or the more than 1000 which have already migrated to the nucleus?
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The first part has been done with yeast already, there's no real barrier to a mouse model at this pointhttps://www.nature.com/articles/s41586-018-0382-x …
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Yeast genome is tiny relative to mammalian genomes, suspect would run into segregation problems if tried to make multi-gigabase chromosomes in mammals. Tbf tulip chromosomes are already there, but plants are weird.
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