why can't our pharma industry make an anxiolytic without side effects that are different but equivalent (or worse) in magnitude to the anxiety they're eliminating
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barbiturates and benzodiazepines can't be used long term. TCAs have an awfully broad binding profile and give you anticholinergic side effects. phenibut and gabapentin rapidly create tolerance. SSRIs and SNRIs are as likely to give you anxiety as fix it and have a wide and
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exciting set of side effects too long to describe here. antihistamines and neuroleptics kill your ability to focus. most TeCAs are also potent antihistamines, so see above. which class did i miss
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okay, we also have opioids (no comment necessary) and sympatholytics, which mess with your blood pressure. also you can't even get clonidine anymore because of criminal abuse of it
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there's probably a dozen of allosteric binding sites on the GABA A/B receptors you could hit with small molecules, get fucking working on it
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okay, there's been recent work on NMDA antagonists like ketamine and analogues, so i'll grant it that something is happening. snowball's chance in hell i'll ever get my hands on pharmaceutical NMDA antagonists but i guess it's good to those who can
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okay#2, i haven't looked well enough, and there's quite a bit of work on novel GABA allosteric modulators, e.g. PM18195453, PM18536733, PMC2574924, 10.1124/jpet.104.066753 that's nice
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GHB is what you're looking for. It was un-patentable and sold OTC, hence the demonization and subsequent scheduling.
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