Daniel Bryan Goodman

@dbgoodman

DNA jockey & dataphile @ UCSF/PICI/Biohub. Engineering the immune system w/ & using DNA synth, multiplex assays & computational modeling.

Vrijeme pridruživanja: svibanj 2009.

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  1. proslijedio/la je Tweet
    prije 20 sati

    We are back with 's OnDeck Seminar Series. This Thursday evening, , founder of (YC S18), will talk about the tech behind the co, and where they are headed. Food at 5:30; talk at 6:00. Please sign up here

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  2. proslijedio/la je Tweet
    31. sij

    I was really excited when I saw some positive events in my dot plot. So I gated them and displayed a new dot plot next to the original one to look into this further, but the events disappeared! I was gating the laptop screen dirt.

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  3. proslijedio/la je Tweet
    26. sij

    Nice PhIP-Seq study from DeRisi & Anderson Labs: Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by PhIP-Seq

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  4. proslijedio/la je Tweet
    24. sij

    This has been a really fun one! challenging the wisdom that one needs a lot of data to do ML guided biodesign. In fact, if you have to choose, think about getting HQ small-N data aligned w your endpoint, vs HT proxy data. low-N ML now helps you succeed w the former!

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  5. proslijedio/la je Tweet
    23. sij

    5-year predictions 1. Active learning in biology - confluence of design (ML), build (large-scale dna synth/edit), and test (multiplexed assays) allows massive scale for exploring new function. Will require programmatic ways to explore that space. Expmnts no longer limiting. [1/n]

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  6. proslijedio/la je Tweet
    16. sij

    It's time to replace λBeta in MAGE, DIvERGE and ssDNA recombineering! By analyzing 100s of proteins, we have identified 2 that allow E.coli oligo-recombineering with up to 50% efficiency, increase multiplexability + allow MAGE in P. aeruginosa – mjesto: Harvard Medical School New Research Building

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  7. proslijedio/la je Tweet
    15. sij

    Innovative analysis of a continuum of single-cell expression using Pareto task inference. Fibroblasts trade-off several biological functions in the tumor micro-environment.

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  8. proslijedio/la je Tweet

    An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

    , , i još njih 2
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  9. proslijedio/la je Tweet
    10. sij

    Assistant Prof. Vs. Full Professor getting a grant.

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  10. proslijedio/la je Tweet
    9. sij

    We find granzyme positive CD8 T cells next to degenerating neurons in hippocampi of Alzheimer’s patients. A smoking gun and a dead body but more work will be needed to prove that that gun killed the neuron. More here and here

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  11. proslijedio/la je Tweet
    9. sij

    It seems just a matter of time until we fully conclude that the adaptive immune system is keeping tabs on nearly every healthy and diseased state. How many semi-dormant viruses do we all have by now in various tissues? Great find

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  12. proslijedio/la je Tweet
    6. sij

    Newest work from and from the lab on comprehensively exploring E. coli promoter function. Blog post/tweetstorm coming on this work, but in the meantime if you have comments/thoughts, we plan on submitting in the next few weeks.

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  13. 4. sij

    Few things get molecular biologists more riled up than restriction enzyme pronunciation. just walked into a minefield.

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  14. proslijedio/la je Tweet
    3. sij

    2020 will be the decade of cell therapy and genome engineering

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  15. 3. sij
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  16. proslijedio/la je Tweet
    1. sij

    faculty on website // faculty in person

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  17. proslijedio/la je Tweet
    27. pro 2019.

    1) Create a community around obsessive enjoyment of something 2) Community becomes productive & high status 3) Wages & status attract careerists to the field 4) Signaling games arise to separate careerists from real obsessives 5) Careerists find this stressful and complain

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  18. proslijedio/la je Tweet

    Handmade bacteriophage. Now thats what the want to see and work with. The best way to study small creatures. The scientist's puppet...!

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  19. 25. pro 2019.

    In case anyone else is planning to make this (or just likes it when food is science-d), do yourself a favor and read : - just don't expect it to stop people from arguing about pudding.

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  20. 25. pro 2019.

    Making Yorkshire pudding, and no matter which recipe I read, there is always one comment that says "I'm British, and this recipe is wrong: ...". Rolled my eyes, but then realized I have similar feelings about DNA prep and cloning protocols.

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