David R. Liu

@davidrliu

David R. Liu is a professor at the Broad Institute, Harvard &HHMI. His lab integrates chemistry & evolution to illuminate biology and enable novel therapeutics.

Massachusetts, USA
Vrijeme pridruživanja: studeni 2008.

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  1. proslijedio/la je Tweet

    A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

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  2. prije 5 sati

    New paper on online at Nature (spoiler: it appears to have evolved from a very closely related bat coronavirus, not from the lab of Dr. Evil, and enters human cells using the same receptor as 2003 SARS).

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    1. velj
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  4. proslijedio/la je Tweet
    28. sij

    Cool idea. Will be interesting to see its applications. Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins: Cell Chemical Biology

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  5. 2. velj

    So no conspiracy theory is needed to explain how could acquire the ability to enter human cells and propagate in vivo (as shown in the paper)—it is evolutionarily poised to do so. Thank you and others for sharing this paper.

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  6. 2. velj

    2015 paper showing how a Chinese bat recombined with a SARS-CoV can use ACE2 to efficiently enter human airway cells and replicate, suggesting “a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.”

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  7. 1. velj

    Good to know that even in a post-truth era, facts and math can still occasionally prevail.

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  8. proslijedio/la je Tweet
    31. sij

    alright all you terrified dorks let me show you how to search for matching protein sequences because there is a CERTAIN GARBAGE PAPER OUT THERE

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  9. 1. velj

    Kudos to , , and others for doing a more thorough analysis and debunking the implied conspiracy theory.

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  10. 1. velj

    The mere claim that such short inserts support nCoV origins "unlikely to be fortuitous in nature" [sic] is already highly suspect. This is a classic case of searching for lost keys only under a lamppost. A fearful world does not need to fuel conspiracy theories with bad analyses.

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  11. proslijedio/la je Tweet
    29. sij

    A big milestone on the road to a synthetic self-replicating RNA world! From Gerald Joyce's and David Horning's team at the Salk.

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  12. 30. sij

    Thank you, and . I’m very fortunate to work with a terrific team of students led by postdoc Andrew Anzalone who actually did the work for this study 🙏

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  13. proslijedio/la je Tweet
    30. sij

    A prime example of a great explainer for a complex topic: my brilliant friend , aka Gene Editor, explains genome editing and search-and-replace (prime) editing re:

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  14. 29. sij

    For those contemplating an academic job search:

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  15. 28. sij

    This manuscript also estimates R0 at 3.8 (95% CI = 3.6-4.0) and, perhaps most surprising to me, predicts that blocking 99% of travel to and from Wuhan will only have a modest effect on limiting the size of the epidemic outside Wuhan.

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  16. proslijedio/la je Tweet
    28. sij

    New topic page collects articles and other resources on the 2019 Novel Coronavirus outbreak, including clinical reports, management guidelines, and commentary. All NEJM content is free full text.

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    27. sij
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  18. 28. sij
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  19. proslijedio/la je Tweet

    Missed 's talk "Listening to Probes: Individuals and Populations"? Tune in to listen to his engaging tales of chemical discovery here:

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  20. 27. sij

    Kudos for dropping the paywall on these articles. I hope all journals will do so as well, especially during times of urgent public need when rapid sharing of data is already having a positive impact on research.

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