David J Glass

@davidjglassMD

Author: Experimental Design for Biologists. Co-editor-in-chief: Skeletal Muscle. Scientist: Aging; Muscle. Works for a biotech company; views are mine.

New York
Vrijeme pridruživanja: prosinac 2013.

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  1. 2. velj

    in honor of Palindrome day, I'm planning dinner that begins and ends with dessert...

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  2. 2. velj

    In case any of you out there are writing a spy novel with some science in it, and need a cool new way to develop bioweapons by combining various snake toxins... here you go... Snake Venom Gland Organoids - for the Ernst Stavro Blofeld in you...

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  3. 2. velj

    Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators ,

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  4. 2. velj

    Moved from Cambridge, MA to Tarrytown, NY... really miss - M. Scelfo, please open a restaurant in Tarrytown... oysters and uni bucatini... and wine...; also of course , and Momi Nonmi...

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  5. 2. velj

    As I'm sure you're all aware, today is 02/02/2020, a Palindrome (in both US and European Convention) ... the first such since the year 01/01/1010... so please be respectful, and speak only sentences today that are the same backwards and forwards: "Never Odd Or Even" for example.

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  6. 31. sij

    Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on skeletal muscle structure and function

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  7. proslijedio/la je Tweet
    29. sij

    Post-hoc hypothesis formulations run afoul of the "Texas sharpshooter fallacy". If you draw targets around randomly-shot arrows post-hoc, (making it appear as if you meant to shoot arrows in this pattern) you "privilege" the data, making a novice look like a sharpshooter.

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  8. proslijedio/la je Tweet
    28. sij
    Odgovor korisniku/ci

    I appreciated the distinction between models and hypotheses, besides the nice historical excursus. We also covered some of these aspects in a recent work

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  9. 29. sij

    Post-hoc hypothesis formulations run afoul of the "Texas sharpshooter fallacy". If you draw targets around randomly-shot arrows post-hoc, (making it appear as if you meant to shoot arrows in this pattern) you "privilege" the data, making a novice look like a sharpshooter.

    Poništi
  10. 28. sij

    For people who think the scientific method must involved hypothesis falsification, it may surprise you to know that Popperian falsification is a relatively recent development. Here's a brief history of the hypothesis, as a framework for experimentation:

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  11. 28. sij

    Skeletal muscle science is odd; experts in these areas rarely mix: Ca++ signaling (Ryr1, etc); genetic diseases; adult biology - atrophy/hypertrophy etc; development; satellite cells/stem cells; genetic diseases, dystrophies, myopathies; let's get everyone together

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  12. 26. sij

    Before you do an experiment, you need to make sure your system has been validated. Let Kontrol Kitty explain:

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  13. 20. sij

    Death by guns is the #1 cause of preventable mortality in the United States - so this is a public health issue as well; all physicians should be battling the NRA and politicians who fight sensible gun control. We had an assault weapons ban; it should be reinstated.

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  14. 20. sij

    Hi all, in case you needed a reminder why we need gun control. These people are NOT militia; they're idiots with assault weapons - that's not what the founders had in mind, and it's not anti-constitutional to take these military weapons away from these dangerous people.

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  15. 19. sij

    From a pure debate-coaching point of view, this is the sort of desperation move you make if you can't counter on the facts; given that, you argue the facts don't add up to a loss. Of course with fair judging, the odds of winning with that strat would be close to zero.

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  16. 19. sij

    The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells

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  17. 19. sij
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  18. 18. sij

    Very disappointed listening to my local sports radio station ; multiple hosts shrugging off cheating in baseball, justifying it as "everyone does it," sending a terrible message. If you don't punish cheating, you're punishing honest players who dont cheat

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  19. proslijedio/la je Tweet
    15. sij

    Excellent session yesterday discussing hot take "A critique of the hypothesis, and a defense of the question, as a framework for experimentation." Thanks for the suggestion

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  20. proslijedio/la je Tweet
    16. sij

    Great talk today at the CVI Seminar given by Dr. ! Thank you for the valuable advice/discussion about reproducibility, data validation, and question-driven experiments during lunch

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