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  1. Prikvačeni tweet
    15. sij

    New on synapse-resolution reconstruction of motor control circuits in the Drosophila ventral nerve cord (VNC) led by , , and Brett Graham. A great collaboration with the labs of & . 1/n

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  2. 15. sij

    We are grateful for the support of & the efforts of those who made it possible including , , @TriNguy81821638, , , Brendan Shanny & . 11/end

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  3. 15. sij

    Our evidence suggests that bCS neurons are poised to drive fast, synchronous leg flexion in response to changes in load on the legs. We expect future functional experiments will further characterize the role of these neurons in behavior. 10/n

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  4. 15. sij

    Indeed, these sensory neurons specifically target motor neurons that control rapid flexion of the leg, but avoid synapsing onto motor neurons that produce slow movements. These motor neuron types were recently characterized by et al (). 9/n

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  5. 15. sij

    We wanted to know if bCS axons target their synapses to particular types of motor neurons. By registering the EM dataset to a standardized VNC atlas, we can compare any EM reconstructed neurons to neurons imaged with light microscopy. 8/n

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  6. 15. sij

    One highlight was finding a class of sensory neurons with huge-diameter axons that synapse on specific leg motor neurons on both sides of the body. We believe these are bilateral campaniform sensillum (bCS) neurons that encode changes in the load on the legs. 7/n

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  7. 15. sij

    We found that most motor neurons had unique and recognizable branching patterns. This let us find left-right pairs of motor neurons that likely control the same muscle in opposite legs. Identifiability of motor neurons is a key advantage to studying motor control in the fly. 6/n

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  8. 15. sij

    We reconstructed all the motor neurons controlling the legs, wings, halteres, and neck; as well as the axons of hundreds of sensory neurons projecting into the VNC from the body. We make these publicly available (see the link above) to serve as a foundation for future work. 5/n

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  9. 15. sij

    We built a GridTape-compatible electron microscope to image over 20 million synapse-resolution images in 2 months. You can see the aligned dataset yourself at Thanks to for publicly hosting the dataset! 4/n

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  10. 15. sij

    To reconstruct the connectivity of neuronal circuits underlying behavior, we developed GridTape to automate the collection of sections for transmission electron microscopy. We used GridTape to collect 4400 sections of a fly VNC in 28 continuous hours. 3/n

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  11. 15. sij

    The VNC has circuits that sense & control the fly's limbs, similar to the spinal cord. Although it accounts for ~1/3 of the central nervous system, our understanding of the anatomy and function of the VNC has lagged behind our understanding of the fly brain. vid E. Dickinson 2/n

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  12. proslijedio/la je Tweet
    31. svi 2019.

    Very exciting, new horizons ahead! X-ray holography to explore neural tissue at the nanoscale with 3D isotropic resolution.

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  13. proslijedio/la je Tweet

    Very excited to share my first scientific paper with the world! X-ray imaging of neural circuits. Included videos show off the beautiful data. As a scientist, my favorite vids are 1 (fly brain) 4 (fly leg) and 5 ( reconstructions)

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  14. 30. svi 2019.
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  15. 5. stu 2018.

    Tomorrow (11/6) morning at I'll be presenting 's work via dynamic poster (DP08). Stop by if you're interested in the structure of a microcircuit that supported sequence activity in parietal cortex.

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  16. proslijedio/la je Tweet
    19. srp 2018.

    Paper is out! Whole-brain electron microscopy volume of adult fruit fly at synaptic resolution video abstract: Download dataset + preconfigured tracing server at: Thanks again to everyone involved!

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  17. proslijedio/la je Tweet
    27. lip 2018.

    : A postdoc position is available in the Lee Lab at investigating neural circuits

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  18. proslijedio/la je Tweet
    9. stu 2017.

    The Jeanne Lab is now open at Yale School of Medicine! We are studying circuit mechanisms of neural computation in Drosophila! Join us!

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  19. proslijedio/la je Tweet
    21. srp 2017.

    mosca lab is hiring! we have exciting new funding for a postdoc to study synapse development! come do great science.

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  20. proslijedio/la je Tweet
    9. kol 2017.

    Sometimes when an article looks a little too relevant to your work, it turns out to actually be about your work.

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