The precisely coordinated cell movements of the early embryo are key to how organisms form different tissues.
Here are some of those movements in all their glory, captured in a 12-hour timelapse of a zebrafish embryo by ’s + #ImagingTheFuture
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Our mission is to make fundamental discoveries and to develop new technologies that will help to cure, prevent, or manage all disease by the end of the century.
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We're proud to have supported this important new work by looking at genetic mutations in long-lived corals and how those mutations may actually result in better adaptation to changing climates.
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Some corals live to be hundreds and, even thousands of years old. They were born with genes that were successful back in their parent’s generation, so how can these old corals still be successful now? Especially in a changing climate?
stanford.io/3JaCayP
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The #PhysicsofLife opened with a fascinating keynote by biophysicist Stephan Grill about how the laws of physics apply to living matter structuring itself into molecules, cells, & tissues. Tune in now to hear other talks.
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Join us next Monday for the CZ Biohub #PhysicsofLife Symposium, on the physics of living systems! Our in-person capacity is full, but all sessions will be livestreamed. Check out our lineup of speakers (all submitted talks are by non-PIs):
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Fascinating research with implications for human evolution led by Katie Pollard, Biohub Investigator and director of the of Data Science and Biotechnology:
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Many changes to the genomes of early humans had opposing effects from each other, possibly because of a delicate balance between improved cognition and psychiatric disease risk
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If the test is negative for all 3, the sample will undergo metagenomic sequencing to see what else may be surging.
Joe DeRisi said of the method: “These are all things that lead to making better diagnostics and intervention — but you don’t get that by not asking the question.”
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Have respiratory symptoms and negative for covid, flu, & RSV? Metagenomic sequencing may tell you what it is.
Biohub is partnering with & to test for the 3 viruses in an "all-in-one" test and determine if anything is surging in the Bay.
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You’re coughing, you’re feverish, but it’s not Covid-19. Recent hospital data suggest it could be RSV or the flu… or it could be something else entirely.
The 24th and Capp Street site will figure it out for you. All you gotta do is swab. Via @AnnikaHom
missionlocal.org/2023/01/test-f
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We had fun hosting & his family at the Biohub. In his first episode on Biohub's work, he talked to & about our mission to cure, prevent, or manage all disease & how a UV 🔬 could be a better way to diagnose malaria. bit.ly/3ZvSNe4
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"We've just scratched the surface of evolutionary relationships between cell types across organisms."
, 's Head of Science, joined to discuss what we’ve learned from a decade of cell atlases & what's left to discover.
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#THISGenFaculty Symposium held last month featured research highlights & lab Intro talks talks from stellar faculty of color across , , & !
Watch the talks here: bit.ly/3ItQ92e
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The Biohub BioE team has created a UV microscope equipped with machine learning that can diagnose malaria faster, cheaper, and more accurately. The potential life-saving device is now undergoing field tests in Uganda w/ and . Learn more:
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Human clinical trials are expected to start in spring 2023. In addition to Biohub & , other contributors to this work are: , , , . n/n
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Kim says: "We now have a formulation that is very inexpensive to manufacture that we think is suitable for use in everybody—including infants, which is a big deal because there is not a good option for young children and infants." 10/n
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Kim's spike design was informed by a Biohub + study done with #Covid patient sera that showed a region of spike elicits very strong antibody activity but not neutralization. After lopping off that section, Kim's vaccine worked much better. bit.ly/3jfnROG 9/n
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Kim says the goal is for the shot to be "cheaper than the syringes containing it." He made a cell line that produces 1000s of doses per liter of cell culture. As a protein-based vax, it’s simpler to make than mRNA vaccines, which need lipid nanoparticles to protect the mRNA. 8/n
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This vaccine could be ideally suited for pediatric vaccination, a huge unmet need globally. The vaccine's sole adjuvant is alum, which has been in use for >90 yrs, incl. in many of the vaccines given to infants, and has an excellent FDA safety profile. 7/n
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What's more, the vaccine was kept at temps up to 37C (99F) for 14 days with no impact on its potency. Having to maintain a cold chain has been one of the obstacles to wider mRNA vaccine distribution in low-income countries. 6/n
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Non-human primates that received a booster more than one year after initial immunization still showed a strong immune response, suggesting that boosters of the vaccine could be required just once a year. 5/n
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In lab experiments, the vaccine elicited an antibody response 100-fold stronger than has been reported for mRNA vaccines—including a strong antibody response against several strains of #coronavirus such as BQ.1 & BQ.1.1. 4/n
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Kim & team designed a vaccine to offer affordable worldwide access. DCFHP, as he calls it, is a ferritin-based nanoparticle that is studded with 8 SARS-CoV-2 spike protein trimers, perfectly structured to create a strong antibody response. 3/n
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Kim's project was driven by the alarmingly low vax rates in low- and middle-income countries. Disease knows no borders, so it's vital that we increase vax rates worldwide. 2/n
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Exciting news! Biohub researcher & prof Peter Kim developed a promising new Covid #vaccine that, in experiments, shows robust protection against all Variants of Concern. Read the preprint &🧵on this work. biorxiv.org/content/10.110 1/n
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As we wind up another exciting year of scientific research & collaboration, we wish you & your family a restful, enjoyable holiday break. See you in the new year!
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From student to Biohub #summerintern to Biohub research associate, Leila Njoya has been motivated by a personal experience. Read how she brings that experience into her work on viral replication & translation in the Kistler lab.
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Winterfest at the Vaccine and Testing Site on 24th and Capp is happening on Friday, December 23 from 9AM-3:30PM! Children 12 and under that get their bivalent/flu shot or get tested for COVID-19 receive a treat and an entry for a chance to win a Nintendo switch! #Health
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The standard diagnostic method for #malaria is time-consuming & error-prone. Our BioE team created what could be a faster, cheaper, & more accurate tool: a UV 🔬 equipped w/ machine learning. We're excited to start field tests with & !
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Apply by 12/31 for the CZ Biohub Summer Internship Program! The 10-week program allows students to conduct exciting research & work closely with scientists and mentors – preparing them to enter #STEMCareers and fostering connections between diverse groups.
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Thrilled for the Knight Initiative’s support to enable our new research!
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Congratulations to the recipients of our inaugural 2022 Brain Resilience Innovation awards! These exciting projects will pursue bold, untried approaches to advance the science of #brainhealth. Read more: neuroscience.stanford.edu/initiatives-an
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Preeclampsia is one of top 3 causes of maternal death globally. Now, a team from has created a prediction model to detect preeclampsia early in pregnancy – which could enable better monitoring and development of more effective treatments.
CZ Biohub’s Summer Internship Program aims to build more diverse teams and foster an inclusive environment in #STEM through hands-on learning and direct mentorship. Learn more and apply by 12/31! #DiversityinSTEM
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We think biology and physics are meant to be together! Learn more at our upcoming Physics of Life symposium. Registration open to all and abstracts accepted from early-career researchers until Jan. 9. Details on our blog:
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Our 2022 Advancing COVID #HealthEquity is out now! See how local Bay Area communities and organizations like , , , and more came together to improve equitable access to care and use inclusive data to drive action.👇
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OpenCell is mapping human proteins one by one – creating a new way to visualize their cellular location and functions. Members of the team presented the #OpenSource platform at #CellBio2022 & spoke with scientists who are using OpenCell in their research.
opencell.czbiohub.org
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At #CellBio2022, accepted the 2022 Innovation in Research award 🎉
The award is for research that significantly impacts progress in the field of cell biology – especially for his work on OpenCell.
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Congrats to the winners of this year’s competition for #NeurIPS2022. Thank you to all those who participated and our co-sponsors for making this the largest #singlecell #AI competition ever!
#machinelearning #drugcreation
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I’m proud of the progress made this year toward measuring human biology in action—from launching the Kempner Institute at to our work to map all cells in the body with 's Tabula Sapiens.
Read our annual letter to learn more: czi.co/AnnualLetter
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The Tabula Sapiens, led by CZ Biohub & created using CZ CELLxGENE technology, is a major step forward in mapping every cell in the human body.
In the annual letter, read how is leveraging collaborations like this to create a better future.
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CZ Biohub is hiring a Scientist/Lab Manager to support 's Quake Lab which works at the nexus of physics, biology, and technology to explore fundamental and medical biological problems. 📝🔬🧪 Share with your network and apply today!
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We are celebrating our community of builders!
Our colleagues and partners made big progress in science, education and supporting our local community.
Read our annual letter: czi.co/AnnualLetter
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So proud: my team receives the 2022 Innovation in Research Award today from . Check out opencell.czbiohub.org at my talk at 5:20p (rm 201) + poster at 12:15p (B615)!! #CellBio2022
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