Vonda Macintyre, _Superluminal_, 1983 - not exactly this plot but most of the pieces. Ordinary humans need to be heavily anesthetized to survive hyperspace; pilots are surgically modified to near-inhumanity so they can remain awake; and the protagonist wakes up during flight...
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artificial anxiety rhythms that can be manipulated to be singularly sourced, a withheld breadth of consciousness unknown to them and easily forgotten but just as easily reimagined through mirrord states of being, amplified subtleties as features of reward
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This has a very Cordwainer Smith vibe, specifically, "Scanners Live in Vain".
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