Christoph Ströck’s Tweets

Gene expression data in the Cornell Center’s latest preprint (tinyurl.com/4e7cdeum) suggests monocytes are receiving signals from tissue under assault—perhaps from infection or injury. More work to do—what are these signals and where are they coming from?

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Thank you very much

for supporting us via the first-ever “Johadamis ME/CFS Research Grant.” 🙌 We are very excited to work with

to identify signs of infection in #ME/CFS blood + cerebrospinal fluid, in concert with

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We are happy to announce the recipient of the 2022 "Johadamis #MECFS Research Grant." Prof. Akiko Iwasaki @VirusesImmunity , in collaboration with @polybioRF , will screen blood + cerebrospinal fluid of a well-defined Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort.

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💙

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Prof. Akiko Iwasaki

My special thank you to @cstroeckw who taught me so much about #MECFS and has been so generous with his effort to educate the public and promote research on this understudied disease

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👉💙

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Prof. Akiko Iwasaki

So grateful to receive the 2022 Johadamis ME/CFS Research Grant! In collaboration with @polybioRF @BjornBragee we will test blood & CSF samples from #MECFS patients for immune phenotypes and antibodies to various pathogens. This will inform us about potential drivers of disease. twitter.com/tempi_stiftung…

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Daniel Loy

@loy_daniel_de

Großartige Nachrichten! Die

fördert ein #MECFS-Forschungsprojekt der

@YaleMed

-Professorin Akiko Iwasaki (

) in Zusammenarbeit mit

@polybioRF

. Es ist sehr wichtig, dass Spitzenforscherinnen auf dem Feld von #MECFS arbeiten. Danke allen Beteiligten!

Quote Tweet

TEMPI-Foundation

We are happy to announce the recipient of the 2022 "Johadamis #MECFS Research Grant." Prof. Akiko Iwasaki @VirusesImmunity , in collaboration with @polybioRF , will screen blood + cerebrospinal fluid of a well-defined Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort.

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Thank you, to everyone involved.

Quote Tweet

TEMPI-Foundation

We are happy to announce the recipient of the 2022 "Johadamis #MECFS Research Grant." Prof. Akiko Iwasaki @VirusesImmunity , in collaboration with @polybioRF , will screen blood + cerebrospinal fluid of a well-defined Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort.

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Eric Topol

@EricTopol

Covid infections disrupt the gut microbiome and increase vulnerability to secondary bloodstream infections nature.com/articles/s4146

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Similarities of #aging and #mecfs are seemingly everywhere!

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Replying to @foundmyfitness

Great timing Rhonda!- I just posted this (my favorite topic, aging biology) pub’d last week. Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging They ID’d age-related

of potentially neurotoxic QA in

. hindawi.com/journals/omcl/

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Eric Vitriol

@chillinwithpfn1

Oct 21

Every mitochondria in a cell imaged over 10 min. Depth-coded LUT (8 μm range). The ability to rapidly image full cell volumes came from a

@christlet

SoRa tip he posted here. Movie uploaded using a

@christlet

trick. LUT from

@christlet

's NeuroCyto Fiji plugin. See the pattern? 🙌

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ME/CFS-Leopold

@cfs_lb

Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotr...

Worsening POTS Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion pubmed.ncbi.nlm.nih.gov/35232225/ The glucose-induced worsening orthostatic tachycardia in POTS occurred while GIP, a splanchnic vasodilator, was maximally elevated.

pubmed.ncbi.nlm.nih.gov

The glucose-induced worsening orthostatic tachycardia in POTS was associated with a decline in SV; these changes occurred while GIP, a splanchnic vasodilator, was maximally elevated.

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If you want to understand how MDs treat #mecfs and #longcovid patients, please dive deeply into this subreddit. I will repeat it. MDs and academics knowing about the severity of these diseases and who stand by idly are part of the problem!

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Cyrus | @CyruxiME@toot.aquilenet.fr

@CyruxiME

Oct 31

Hey @economicsbrooke @CatiaNicodemo, have you seen r/medicine’s reaction to your study? Looks like you hit a sensitive nerve — dead on

reddit.com/r/medicine/com

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Oct 31

On a relative surface level, #aging and #mecfs seem very similar in their pathogenicity.

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Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

New insight into the properties of SPD may facilitate the development of strategies to prevent and improve outcomes of age-related immune pathologies. science.org/doi/abs/10.112

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B cells from old mice induce the generation of inflammatory T cells through metabolic pathways

B cells from old mice induce the generation of inflammatory T cells through metabolic pathway

sciencedirect.com

We have measured the capacity of B cells from young and old mice to induce the differentiation of naïve CD4+ T cells from young mice into pro-inflamma…

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Martin Picard

@MitoPsychoBio

Oct 31

"Given its central importance, it is logical that cells would modulate mitochondrial membrane potential in response to demand and environmental cues [...]". Membrane potential is a widely conserved biological integration site - cell membrane and likely mitochondrial membrane too.

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Jordan Berg

@jordanberg0

Congrats @Yeyunouyang for your pre-print from the @RutterLab coming out today! Check out this fascinating body of work - learn about some fascinating ways mitochondria sense and respond to mitochondrial dysfunction. biorxiv.org/content/10.110

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Oct 30

Vielen Dank für Ihre Hilfe/Unterstützung! 💙

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Michael Stingl

@neurostingl

Oct 30

Wichtige Folge-Empfehlung! Die @Tempi_Stiftung, eine Initiative der Familie Ströck, unter anderem @cstroeckw, fördert Forschung zu #MECFS. Neu mit einem jährlichen $100.000-Grant, zu dem Details in den nächsten Wochen bekannt gegeben werden! tempi-stiftung.at

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AMMES

@AmmesAdmin

Oct 28

"These six genes were further upregulated in the 22 bedridden participants who suffer not only from ME/CFS but also from other autoimmune diseases. These genes are involved in T cell, B cell and autoimmunity functions." ncbi.nlm.nih.gov/pmc/articles/P

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Doctors’ attitudes toward specific medical conditions

Oct 29

(Ugh, one paragraph got lost, but the point I am trying to make comes across nevertheless, I hope)

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is used in a quasi religious manner. It is "where" medicine puts many of the things we don't know or understand. In doing so upholding old dogma. This comes at a high cost for patients in many or most cases. /4

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is or can be psychosomatic, depending on an intuitive process of any given MD or certain specialties (i.e. psychiatrist). No questions asked. It is interesting to note that unfalsifiability is a "no go" in medicine unless it serves the idea of psychosomatism which /3

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The alternative (and unfortunately the status quo in medicine) is ludicrous. At its core, it says that every medical diagnoses must be falsifiable (i.e. biomarker) unless it is psychosomatic. Which means that every disease that can exist but is not understood /2

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Psychosomatic diagnoses shouldn't be existent as long as they are not falsifiable. Even if there were psychosomatic "appearances", and this whole conundrum was not mostly "magical thinking" MDs should be held accountable to (per default) err on the side of caution. /1

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"The results show physicians discuss ME/CFS, depression, and Lyme disease with more negative language [...]. The results for ME/CFS included over four times more negative words than the results for depression."

sciencedirect.com

This study uses machine learning and natural language processing tools to examine the language used by healthcare professionals on a global online for…

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Oct 28

Amazing.

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Our new paper just out @ScienceMagazine! Antiviral activity of a human protein of retroviral origin A study led fearlessly by @jofrank1088 We propose that the human genome encodes a deep pool of antiviral proteins derived from retroviruses! science.org/doi/10.1126/sc

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Rivka

@Rivkatweets

translational-medicine.biomedcentral.com

Wow! 🌟A major pharma, ⁦⁦

@bmsnews

⁩, is investigating genes specific to immune function & viral infection in #MEcfs. Their aim: Identify biomarkers of, & treatments for, ME🌟 Autoimmune gene expression profiling of fingerstick whole blood in CFS

Autoimmune gene expression profiling of fingerstick whole blood in Chronic Fatigue Syndrome -...

Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical, psychological, cognitive, social, and occupational...

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PS: The website and Twitter are at the very bottom of our priority list atm. Tempi is run entirely by very few volunteers; most of our time is used to find and advance good funding opportunities.

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Tempi-Foundation runs its own Twitter profile

now. Please follow to stay up to date. 💙

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Hallo Herr

! Würden Sie uns helfen und untenstehenden Tweet teilen? Wären davon unabhängig für jeden Tipp dankbar! Vielen Dank! 💙

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Arzt/WissenschaftlerIn in Österreich die/der am Interplay von Stoffwechsel und Infektion im Zusammenhang #mecfs forschen möchte und/oder daran interessiert ist am Aufbau einer Forschungsplattform mitzuwirken? Bitte teilen! Bei Interesse: christoph.stroeckcfs@gmail.com

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Michael Stingl

@neurostingl

Liest bei mir jemand mit, wo Interesse an Forschung zu #MECFS besteht?

Quote Tweet

Arzt/WissenschaftlerIn in Österreich die/der am Interplay von Stoffwechsel und Infektion im Zusammenhang #mecfs forschen möchte und/oder daran interessiert ist am Aufbau einer Forschungsplattform mitzuwirken? Bitte teilen! Bei Interesse: christoph.stroeckcfs@gmail.com

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Arzt/WissenschaftlerIn in Österreich die/der am Interplay von Stoffwechsel und Infektion im Zusammenhang #mecfs forschen möchte und/oder daran interessiert ist am Aufbau einer Forschungsplattform mitzuwirken? Bitte teilen! Bei Interesse: christoph.stroeckcfs@gmail.com

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ncbi.nlm.nih.gov/pubmed/21967891 ncbi.nlm.nih.gov/pmc/articles/P journals.plos.org/plospathogens/ ninds.nih.gov/news-events/pr

journals.plos.org

Preexisting and inducible endotoxemia as crucial contributors to the severity of COVID-19 outcomes

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I am not a doctor, but if your gut- and blood-brain barriers are "leaky", you would not necessarily need abnormal standard blood testing to be in big trouble. There is no "normal amount of X" if it travels freely where it should not. #mecfs #longcovid

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#cancer #oncology #neurology #braincancer #neurotwitter #MedEd #MedTwitter #SciComm #AcademicTwitter

Top Biomedical Science

@imedverse

Oct 26

The normal structure and permeability pathways of blood-brain barrier (BBB)

@NatRevClinOncol

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