Casey S-M

@csdashm

How do neural circuits work, anyway?

Ashburn, VA
Vrijeme pridruživanja: prosinac 2013.

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  1. proslijedio/la je Tweet
    3. velj

    The first paper on SciPy, after 19 years - feels so good to finally see this published! Credit goes to all SciPy contributors over all those years, amazing team effort! And thanks to Nature Methods for making it open access!

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  2. proslijedio/la je Tweet
    31. sij

    Weekly lab meeting on Jan 31, 2020. Everyone is wearing black to honor the last day of Gerry Rubin (our Man in Black) as the Exec. Director of . It is nothing short of a monumental achievement to have built Janelia to what it is today.

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  3. proslijedio/la je Tweet
    25. sij

    Most people know Charles Darwin set off on the HMS Beagle as a naturalist to explore the flora & fauna of the world. Very few people know his secret mission was a one-man dunk-fest of the animals he encountered.

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  4. 22. sij

    And now we get Hemibrain Wednesday! I can’t wait to dive into some of this data.

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  5. proslijedio/la je Tweet
    20. sij
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  6. proslijedio/la je Tweet
    17. sij

    This is your periodic reminder that the published ethogram for Caribbean reef squid includes "bad hair" 😂

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  7. proslijedio/la je Tweet
    16. sij

    We got the sequencing results back for our fly anno 1933. 40 million reads! ...and preliminary tests indicate that a good chunk of these reads are Drosophila DNA! Now we do the samples from the 1800s.

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  8. 14. sij

    People working in bad faith is so exhausting.

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  9. 14. sij

    A more charitable question, and one I find more interesting, would be something like “what traits do you associate with the biologists you consider particularly intellectually impressive (even in rooms full of smart people)?” Note that this isn’t the best science per se.

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  10. 14. sij

    Biology does feel different. Not as one-dimensional. But of course it has hard ideas! For instance, some people excel at thinking crisply about strongly interacting systems with lots of parts is hard is something to come up with trees of specific hypotheses and tests.

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  11. 14. sij

    In physics, it’s usually about math, and more specifically about the understanding of how the mathematical structures relate to the physical situation. Everyone in my grad school class was smart, but some people were clearly just sharper at that than others.

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  12. 14. sij

    I understand why people are dunking on this question, but there is a nugget to it. In the standard training in physics, one gets to areas that are at the edge of one’s abilities (e.g. QFT for me), but has a few peers that understand them with relative ease.

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  13. 6. sij

    Well, the OS X Catalina update changing the default terminal shell from bash to zsh was a brief pain, but also a good motivation to learn a new tool. It took an hour or two to get everything set up again (mostly via oh my zsh), but now I’m hooked on the autocomplete hinting and z

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  14. 2. sij

    A multi-author thread (!) about the latent binary nature of L23->L23 excitatory synapses that you can only see when you are able to filter them out from the rest of the inputs onto L23 spines.

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  15. proslijedio/la je Tweet
    2. sij

    Very interesting experimental results: somewhat reminiscent of our old information-theoretic results on distributions of synaptic efficacy

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  16. 31. pro 2019.

    Are cortical excitatory synapses analog or discrete? Being able to analyze 1000’s of synapses from a proofread EM volume finds evidence for two states, one bigger than the other. 1st analysis paper from our EM data, led by , et al!

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  17. proslijedio/la je Tweet
    17. pro 2019.
    Odgovor korisnicima i sljedećem broju korisnika:

    The above points in addition to the absolutely key role CREMI played.

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  18. proslijedio/la je Tweet
    17. pro 2019.
    Odgovor korisnicima i sljedećem broju korisnika:

    1) Completeness is really important. 2) In fly, basic questions about which cell types connect to which were open. So, a strong incentive for manual tracing, which in turn provided training & test data for ML work. 3) Community use made it easier to harvest these data.

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  19. proslijedio/la je Tweet
    13. pro 2019.

    Automatic prediction of synaptic links in a whole Drosophila brain: Read about 's method in our preprint, result of a fruit(fly)ful collaboration with the labs of , , , and !

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  20. 13. pro 2019.
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