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Prikvačeni tweet
Our new preprint is out! "A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila." Short summary thread below.
@Boutroslab@DKFZ#CRISPR#Drosophila https://www.biorxiv.org/content/10.1101/636076v1 …pic.twitter.com/AsViJ2Ih5z
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crisprflydesign proslijedio/la je Tweet
Wow, January 2020 was the warmest on record and greater than 3°C above the 1981-2010 climate average in Europe. The average global temperature was also the highest on record.
More info (@CopernicusECMWF): https://climate.copernicus.eu/surface-air-temperature-january-2020 …pic.twitter.com/fLJOBgKHIl
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Our sgRNA line HD_CFD01270 targets Axin, the ortholog of human tumor-suppressor Axin1. Axin1 is frequently mutated in a variety of cancers, leading to overactive Wnt signaling. CRISPR mutagenesis in flies results in overgrowth and induction of Wnt target gene senseless
pic.twitter.com/0U6eubKM3P
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I can only strongly congratulate
@crisprflydesign and@Boutroslab for their heroic effort! This adds to the power of reverse genetics in flies which has a strong basis with transgenic RNAi through efforts from@VDRC_flies@DRSC_TRiP long live the pioneer organism Drosophilahttps://twitter.com/crisprflydesign/status/1128015203629699072 …
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Congratulations!! Get HD CRISPR library stocks from
@VDRC_flies - currently 1459 sgRNA lines plus 22 toolkit stocks (Cas9 and Cas9/Gal4). Generate loss-of-function mutations in#Drosophila in a germline restricted, ubiquitous or tissue specific fashion. https://stockcenter.vdrc.at/control/library_hdcfd …https://twitter.com/crisprflydesign/status/1224370975199891459 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Apparently there is such a thing as getting a paper accepted directly after first round of reviews. At least that's what just happened to our CRISPR library manuscript at
@eLife. Thanks to the whole team!
https://www.biorxiv.org/content/10.1101/636076v2 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
crisprflydesign proslijedio/la je Tweet
Challenging myself to tweet more! I’ll be sharing a fun fact about
#Drosophila, commonly known as fruit flies, every day in February. Let’s start#FruitFlyFebruary !#scicomm#entomology#edutwitterHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
crisprflydesign proslijedio/la je Tweet
The idea that we can predict what will be "relevant for patients" is counterintuitive to me (crystal balls dont work). Much of what medicine is now excited about (iPS/CRISPR etc) comes from investments in reproducible, well-controlled discovery research. Fund discovery science.https://twitter.com/mariagoneviral/status/1222166858859675649 …
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CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos https://www.biorxiv.org/content/10.1101/2020.01.13.904763v1 … All right, first story from the Moreno-Mateos lab. A great collaboration with the
@BazziniLab . Do you wanna induce knock-down in zebrafish and other animal embryos? Take a look to it :)Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Why did I just find out about this? Goniurellia tridens, the 3-in-1 fruit fly!pic.twitter.com/p0Rfrn2mod
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crisprflydesign proslijedio/la je Tweet
We are looking for two postdoctoral researchers to join our new project at
@COSHeidelberg and@embl . Are you interested in creating novel genetic tools to study signalling, mitosis, etc. across biological scales? Deadline: 18 January. Please RT. Info: https://www.nature.com/naturecareers/job/postdoctoral-positions-in-synthetic-biology-and-cell-biology-centre-for-organismal-studies-cos-heidelberg-uni-heidelberg-712903 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
crisprflydesign proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Climate tipping points - when climate change leads to release of massive amounts of CO2 stored in the environment.
#UniteBehindTheScience#timetoacthttps://twitter.com/billmckibben/status/1213095386887475200 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
crisprflydesign proslijedio/la je Tweet
Class 2 CRISPR Type IV enzymes (
#Cas13) are a new class of RNA-targeting proteins. Little is known about guide RNA design for high targeting efficacy. Together with@alexmenman1 and@nevillesanjana +lab we quantified the effect of 29,000 guide RNAs: (http://doi.org/10.1101/2019.12.27.889089 …) 1/16Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
crisprflydesign proslijedio/la je Tweet
Heidelberg - not only a great place for
#research but likewise a beautiful, inspriring city. Today the castle in a foggy, majestic & christmassy
mood
Merry Christmas from #heidelberg !

pic.twitter.com/17rssqQP2Z
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crisprflydesign proslijedio/la je Tweet
48.9 degrees C on the farm (western Vic) yesterday. Cockies falling dead from the trees. People and wildlife cannot withstand the extremes we are already experiencing and this is just 1 degree of warming. We are on track for more than 4.

#ClimateEmergencypic.twitter.com/cAQacRRP86
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Sums up pretty well the political response to the climate crisis: The Australian PM flying to Hawaii for a holiday while devastating bushfires rage at home following the driest year on record.https://www.theguardian.com/australia-news/2019/dec/21/australian-bushfires-death-toll-rises-as-temperatures-soar-in-severe-heatwave?CMP=Share_iOSApp_Other …
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The Heidelberg CRISPR Fly Design Library is on Flybase. All sgRNA lines now show up in the 'transgenic constructs' tab of each gene report. Thanks
@FlyBaseDotOrg for all your work on this and everything else you do.#Drosophilapic.twitter.com/4tpbBfzsrV
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... is in line with the known role of optix in regulating cell proliferation in the anterior compartment of the wing disc. https://dev.biologists.org/content/144/17/3168.long …pic.twitter.com/JxmxmhQ1Eg
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Fun to confirm the activity of sgRNA lines by inducing very specific phenotypes. Here we tested our line 2306 targeting the transcription factor optix in the wing. Note the reduction in the area between L2 and margin (asterisk). This....pic.twitter.com/BpwxJkV3xg
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Interested in studying Hedgehog signaling in sunny Nice? Then check out this postdoc position in the Therond lab.
#Drosophilahttps://thenode.biologists.com/3-years-post-doc-position-in-developmental-cell-biology-and-physiology/jobs/ …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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