One manifestation of excessively high glucocorticoids like ACTH is Cushing’s Syndrome, whose symptoms are described by Wikipedia in the following way:pic.twitter.com/UIN0wMltDy
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One manifestation of excessively high glucocorticoids like ACTH is Cushing’s Syndrome, whose symptoms are described by Wikipedia in the following way:pic.twitter.com/UIN0wMltDy
So are there populations that have gone the other way: where selection against schiz has taken place? You would expect it to happen in urbanized places of the far north and there is some evidence in the clump of low hanging dots in the CEU sample here.pic.twitter.com/UUocVkP85U
About ¼ of Mormons have Scandinavian surnames, principally Danish and Norwegian, and I think the low hanging cluster of dots on the bottom of CEU represents individuals of majority Scandinavian descent that I know to exist in the dataset.
Scandinavians are under strong selective pressure to keep schizophrenia low, but their high consumption of fish both reduces the power of that pressure and redirects it away from acting directly upon schiz causing alleles and instead improving omega-3 metabolism instead.
The population that has probably been under the most ruthless selection again schiz per se are the Finns, who along with their Estonian cousins have the highest PISA scores in Europe. Pfiffer also calculated them as having highest the Edu Attainment PGS of any Europeans.
Schizophrenia risk increases with every IQ dropped and the same genes that increase schiz risk also impair mental function in normals:https://www.nature.com/articles/s41380-018-0332-x …
Selection against nuttiness may also help to explain the distinctive Nordic personality: in other words, why they’re so boring. The positives to being sane are obvious; the downsides are that you find yourself living in a country where people stare at a burning log on Christmas.
There's a lot more to write about this, but these are the big points. In my next dealie I'm going to try to figure out what changed around 1985 that led to the current autism explosion and explain how it affected even non-autistic millenials.
You can seem some recent numbers here. Not state by state, but the highest prevalence of schiz in North American whites has been found in Alberta, highest European rates are in Finns.https://academic.oup.com/schizophreniabulletin/article/35/3/582/1874387 …
The studies comparing African Americans to whites show no difference in Los Angeles but a significant black excess in the rest of the country.
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