But in general, exiting cells is actually very hard. SAR-CoV-2 has its own exit mechanism, but it is not part of the S protein. So unlike SAR-CoV-2 which _can_ exit your cell after reproduction, S alone cannot.
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Replying to @cmuratori
This would likely be fine if the protein was very clearly only produced within the deltoid muscle receiving the injection. I’m not convinced that’s the case.
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Replying to @webdevMason
It definitely is not the case. That is not part of the safety, as far as I know - it is expected that the protein will be produced elsewhere. The key part is that it cannot leave the cell.
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Replying to @cmuratori @webdevMason
S causes problems because it can bind to the _outside_ of cell walls. It doesn't have any bindings for things _inside_ cells. So the reason the vaccine S doesn't cause the havoc that the real S does is because it doesn't get outside the cell where it can bind and disrupt.
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Replying to @cmuratori @webdevMason
I definitely don't want to suggest you do something you don't want to do, so if you're uncomfortable with the vaccine, that is the end of the story for sure. But I also just wanted to make sure that the information is out there, because it is hard to find :(
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Replying to @cmuratori @webdevMason
So I just wanted to underscore that the design of the vaccine is a) fully aware that the protein will not only be produced at the site, b) fully aware that the S protein is dangerous outside the cell, and c) the beauty of mRNA tech is that it doesn't matter :)
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Replying to @cmuratori @webdevMason
M. Eric DeFazio Retweeted Robert W Malone, MD
not trying to be edgy, but this is from the inventor of the mRNA vaccine:https://twitter.com/RWMaloneMD/status/1403836354098872322 …
M. Eric DeFazio added,
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Replying to @edefazio @webdevMason
Just to be clear, I would never suggest that vaccines do not have safety issues. All vaccines have safety issues, mRNA or otherwise. I am merely tying to point out that dumping S protein into your bloodstream is not one of the potential issues.
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Hi Casey, there's a study seems to show otherwise.https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075# …
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That is a great study, and one that I asked for multiple times (including directly from a person who worked at Pfizer) but no one appeared to have done one. It is expected that a (very low) amount of S would be detectable due to random events, but I'm not sure how high...
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Looking at the paper, most of the results look like they would be in line with that expectation, except for a few of the patients who look like they have almost infection-like S1 levels. It would be nice to hear an expert analyze this.
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Replying to @cmuratori @joshux321 and
Spike proteins produced by mRNA shots do get released into the bloodstream when T-cells kill the cell, and the Novavax shot injects the spike itself. This article which goes over the whole spike proteins in the bloodstream in an accessible way:https://blogs.sciencemag.org/pipeline/archives/2021/06/15/the-novavax-vaccine-data-and-spike-proteins-in-general …
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