The other study that concerns me shows that the vaccine’s lipid nanoparticles— which carry the RNA instructions for the spike protein — move beyond the deltoid muscle they’re injected into and accumulate in other tissues, and seem to accumulate in ovarian tissue preferentially.
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That study looked at a *very* small sample, but given what we *think* we know about the spike protein — it likely causes some degree of tissue damage on its own, independent of the virus — it’s something that definitely demands further study
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Replying to @webdevMason
I had similar concerns about the spike protein. Looking into it, however, it is very important to note that the mRNA vaccines produce the spike protein _inside_ your cells, which they then cannot exit. This is a crucial factor in the vaccine strategy.
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Replying to @cmuratori @webdevMason
So unlike studies of S1 or S put in the bloodstream, the modified S made by the vaccine is made inside the ER and does not have an exit mechanism _other than dendrite presentation_, which is exactly what you want.
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Replying to @cmuratori @webdevMason
Twitter's not a great medium for discussion such things, but I would just say, I was delighted by the science behind the mRNA vaccines, and despite having the same S-protein concerns, after thorough research I happily went and got the Pfizer shots.
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Replying to @cmuratori @webdevMason
But in general, exiting cells is actually very hard. SAR-CoV-2 has its own exit mechanism, but it is not part of the S protein. So unlike SAR-CoV-2 which _can_ exit your cell after reproduction, S alone cannot.
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Replying to @cmuratori
This would likely be fine if the protein was very clearly only produced within the deltoid muscle receiving the injection. I’m not convinced that’s the case.
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Replying to @webdevMason
It definitely is not the case. That is not part of the safety, as far as I know - it is expected that the protein will be produced elsewhere. The key part is that it cannot leave the cell.
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Replying to @cmuratori @webdevMason
S causes problems because it can bind to the _outside_ of cell walls. It doesn't have any bindings for things _inside_ cells. So the reason the vaccine S doesn't cause the havoc that the real S does is because it doesn't get outside the cell where it can bind and disrupt.
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I definitely don't want to suggest you do something you don't want to do, so if you're uncomfortable with the vaccine, that is the end of the story for sure. But I also just wanted to make sure that the information is out there, because it is hard to find :(
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Replying to @cmuratori @webdevMason
So I just wanted to underscore that the design of the vaccine is a) fully aware that the protein will not only be produced at the site, b) fully aware that the S protein is dangerous outside the cell, and c) the beauty of mRNA tech is that it doesn't matter :)
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Replying to @cmuratori @webdevMason
M. Eric DeFazio Retweeted Robert W Malone, MD
not trying to be edgy, but this is from the inventor of the mRNA vaccine:https://twitter.com/RWMaloneMD/status/1403836354098872322 …
M. Eric DeFazio added,
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