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2/ Or even more mind-bendingly, there isn't just a "root" cause but really a combination of things that wind up being bad together but not in isolation. Thus having a habit of constantly reevaluating your conclusions about what works and what doesn't is crucial.
3/ It's also a big pain in the butt. But that's the nature of dealing with things this complex. You have to appreciate that you're going to be wrong a lot. Probably most of the time in some way.
Reminds me of that blog post http://johnsalvatier.org/blog/2017/reality-has-a-surprising-amount-of-detail …
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