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2/ It's one thing to be wrong occasionally (as in software engineering) and to swallow your pride, correct course and move on. But having that be the norm can really be demoralizing.
3/ It's tempting to fall in love with ideas and to start looking for evidence that you're right (confirmation bias) instead of trying to uncover the very likely scenario that you're wrong. This is a constant battle for me. I'd imagine this is true for others as well.
4/ I'd say the value of the "emotional intelligence" component of research and venturing into the unknown isn't something I've heard talked about much but it's very real to me.
5/ In fact I'd say most log jams in my progress in research revolve around allowing ego to take over rather than being disciplined about following the evidence. In particular, clever theories of mine are particularly difficult to discard when the evidence just doesn't pan out.
6/ I'm just putting this all out there in case anybody feels weird/alone/stupid about running into these same situations.
Tweet (1) is explained by the fact that you're not doing engineering anymore... It's one of the biggest signs that you've stepped into the room just next to it: science.
In fact, tweet (2) is the only thing I need to know to say you're doing science 
https://twitter.com/sina_lana/status/948940496268804096?s=19 …
I've made that my pinned tweet because it helps me letting go when I really wished my theory was true but it's clearly wrong; and it helps me understand the "why" when I read about people purposefully doing bad science.
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