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Here’s some fresh science from my postdoc work with 
+ Python package by @gretton_dana
...introducing Pyhamilton!!
"Flexible open-source automation for robotic bioengineering"
@erika_alden_d @kesvelt
@HamiltonRobotic
Here goes… (thread) 1/n
https://www.biorxiv.org/content/10.1101/2020.04.14.041368v1 …pic.twitter.com/qYQRINA059
You may have used a liquid-handling robot... very powerful. But the types of experiments you can do is limited by their SOFTWARE not their hardware.
Many of these get stuck doing repetitive processes or end up in a corner 
This is where Pyhamilton comes in... 2/n
To do far more complex experiments, we needed an easy to use (but not easy to develop @gretton_dana) software package so we could take full advantage of these robots. #Pyhamilton enables that. With just a few lines of python code we can double the speed of lab assays…. 3/npic.twitter.com/cxupaTo8U5
**** NOTE: This is NOT psuedo-code. This is THE code. Get it here: https://github.com/dgretton/pyhamilton … @gretton_dana ….. 4/n
Freed from geometric or line-by-line programming restraints, we can now do all sorts of new experiments like simulating population dynamics. Why specify hundreds of different pipetting steps, when you could just use a matrix to simulate a geographical barrier?.... 5/npic.twitter.com/AOyXoPc2eU
Last week, we gave you PRANCE, which used 1 turbidostat and 100 evolving lagoons. But what if you wanted 500 *different turbidostats* WITH real-time reporter monitoring.... trivial with #Pyhamilton... 6/npic.twitter.com/r2PBCOTXCH
What would anyone want with 500 turbidostats, you ask? How about screening whole knockout collections or small molecule libraries for days without user intervention using any fluorescent readout (pH, CO2, gene expression, etc.) Well, here's what we did... 7/n
We sampled the entire metabolic fitness landscape with chemical permutations of C, N, and P for the effect on protein expression and growth. 100 different media compositions, 36 hours log-phase growth, in triplicate, no user intervention, with REPORTER MONITORING.... 8/npic.twitter.com/ATGTvQGme5
We also learned some pretty cool stuff, like in phosphorus limiting conditions (like soil, some lakes), bacteria can compensate for growth defects with carbon supplementation and actually shunt from mRNA/DNA expression to protein expression!…. 9/npic.twitter.com/Ppwvhspugu
We’re so excited by the potential of being able to tackle all sorts of new questions with #Pyhamilton. We've made this package #opensource and freely available in the hopes it will inspire scientists to use to take on their own challenges and unique ideas…. 10/n
I had an absolute blast working on this with @gretton_dana, @erika_alden_d and @kesvelt. Big shoutout to @HamiltonRobotic for their help and for the amazing robots that made this possible.
We hope you'll read, share, and USE!.... fin.
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