1/ Happy to help, although I’m not sure why this paper, focused on technical issues about buccal epithelium and a new microarray platform from @illumina, is prompting curiosity.
I’m going to skip the probe performance, guessing that’s not what interests you
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2/ The DNA methylation is more correlated between MZ twins than unrelated pairs (Fig. 3d), unsurprising given how much of an influence DNA sequence variation is known to have on DNA methylation. Fig. 3h is an abomination in the eyes of the Lord, but moving on…
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3/ Nice that they also explore how much variation is due to cell subtype proportional differences, another clear contributor to variation in DNA methylation in their data (Fig. 3e)
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4/ Their mQTL analysis (methylation quantitative trait loci, sequence variants affecting DNA methylation) is based on 84 twins, probably underpowered. They end up with very large numbers, guessing there’s some noise there
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5/ They show that the changes in DNA methylation attributed to mQTLs are enriched at sites that are DNase hypersensitive in epithelial cells, likely to be regulatory. This increases confidence in at least that subset of their findings
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6/ They’re not really trying to show that DNA methylation changes occur that cannot be attributed to cell subtype proportion or DNA sequence variation. Pretty simple study, thoughtfully done, not over-claiming.
End of conversation
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Unless it means everything is genetically determined we don't want to hear about it.
Thanks. Twitter will use this to make your timeline better. UndoUndo
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Sometimes I need someone to translate @charlesmurray tweets!Thanks. Twitter will use this to make your timeline better. UndoUndo
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Please retweet if you get a response
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This book gives credence to black people’s claims that anti-black white supremacist terrorism has never stopped for the past 500yrs. According to this author the well documented