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charlesmurray's profile
Charles Murray
Charles Murray
Charles Murray
@charlesmurray

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Charles Murray

@charlesmurray

Husband, father, social scientist, writer, Madisonian. Or maybe right-wing ideologue, pseudoscientist, evil. Opinions differ.

Burkittsville, MD
aei.org/scholar/charle…
Joined February 2009

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    Charles Murray‏ @charlesmurray Sep 26

    We non-geneticists could use a little help translating the conclusion here. @EpgntxEinstein? @WiringTheBrain? Anyone?…https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-018-0225-x …

    3:40 AM - 26 Sep 2018 from Maryland, USA
    • 2 Retweets
    • 6 Likes
    • Estefanía Sánchez-Vásquez Raphi Sirt Dark Matter DeCode Brett P Andersen Fantô ain't goin' back to infantry Engy Kpi
    4 replies 2 retweets 6 likes
      1. New conversation
      2. Einstein Epigenomics‏ @EpgntxEinstein Sep 26
        Replying to @charlesmurray @WiringTheBrain

        1/ Happy to help, although I’m not sure why this paper, focused on technical issues about buccal epithelium and a new microarray platform from @illumina, is prompting curiosity. I’m going to skip the probe performance, guessing that’s not what interests you

        1 reply 0 retweets 0 likes
      3. Einstein Epigenomics‏ @EpgntxEinstein Sep 26
        Replying to @EpgntxEinstein @charlesmurray and

        2/ The DNA methylation is more correlated between MZ twins than unrelated pairs (Fig. 3d), unsurprising given how much of an influence DNA sequence variation is known to have on DNA methylation. Fig. 3h is an abomination in the eyes of the Lord, but moving on…

        1 reply 0 retweets 1 like
      4. Einstein Epigenomics‏ @EpgntxEinstein Sep 26
        Replying to @EpgntxEinstein @charlesmurray and

        3/ Nice that they also explore how much variation is due to cell subtype proportional differences, another clear contributor to variation in DNA methylation in their data (Fig. 3e)

        1 reply 0 retweets 2 likes
      5. Einstein Epigenomics‏ @EpgntxEinstein Sep 26
        Replying to @EpgntxEinstein @charlesmurray and

        4/ Their mQTL analysis (methylation quantitative trait loci, sequence variants affecting DNA methylation) is based on 84 twins, probably underpowered. They end up with very large numbers, guessing there’s some noise there

        1 reply 0 retweets 0 likes
      6. Einstein Epigenomics‏ @EpgntxEinstein Sep 26
        Replying to @EpgntxEinstein @charlesmurray and

        5/ They show that the changes in DNA methylation attributed to mQTLs are enriched at sites that are DNase hypersensitive in epithelial cells, likely to be regulatory. This increases confidence in at least that subset of their findings

        1 reply 0 retweets 0 likes
      7. Einstein Epigenomics‏ @EpgntxEinstein Sep 26
        Replying to @EpgntxEinstein @charlesmurray and

        6/ They’re not really trying to show that DNA methylation changes occur that cannot be attributed to cell subtype proportion or DNA sequence variation. Pretty simple study, thoughtfully done, not over-claiming.

        0 replies 0 retweets 0 likes
      8. End of conversation
      1. Ted Herman‏ @tedherman Sep 26
        Replying to @charlesmurray @EpgntxEinstein @WiringTheBrain

        Unless it means everything is genetically determined we don't want to hear about it.

        0 replies 0 retweets 0 likes
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      1. A Mazed‏ @justamazd Sep 26
        Replying to @charlesmurray @EpgntxEinstein @WiringTheBrain

        🤷🏼‍♀️Sometimes I need someone to translate @charlesmurray tweets!

        0 replies 0 retweets 0 likes
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      1. New conversation
      2. K-Dog‏ @Dogtheconqueror Sep 26
        Replying to @charlesmurray @EpgntxEinstein @WiringTheBrain

        Please retweet if you get a response

        2 replies 0 retweets 0 likes
      3. Anti Racism‏ @anti_racism101 Sep 26
        Replying to @Dogtheconqueror @charlesmurray and

        Anti Racism Retweeted Anti Racism

        https://twitter.com/anti_racism101/status/1044917060587978753 …

        Anti Racism added,

        Anti Racism @anti_racism101
        👌This book gives credence to black people’s claims that anti-black white supremacist terrorism has never stopped for the past 500yrs. According to this author the well documented #whitesupremacist personality flaw is passed down. How do you weasel around that conclusion? https://twitter.com/charlesmurray/status/1044672142502170624 …
        Show this thread
        0 replies 0 retweets 0 likes
      4. End of conversation

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