"man is a social animal" sounds all fluffy bunnies but what it means is that there are deep structures in your brain that try to kill you if your perception of your social status is too low. in Dunbar-number-sized social groups most people could clear this bar. most now can't
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Thinking of it as a bomb might make sense evolutionarily if its detonation typically took the form of high-risk high-reward run amok. In modern society, that’s less encouraged (though maybe increasingly popular) and a higher percentage wallow impotently instead.
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Otherwise the idea of depression as a natural/adaptive reinforced downward spiral remains dubious
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