Intoxicating / psychoactive substances and my reactions to them: • Alcohol — very effective (likely exacerbated by my daily dose of venlafaxine) • Marijuana — nothing • Modafinil — nothing • Kava — mild effect; needs more experimentation • Nicotine — effective
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i do not i am afraid :(
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you could try bugging Gwern, seems like something he might know
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no but also those are prodrugs and not as good, did you hear that you can get hell of drugs shipped from Fiji, the Land The FDA Forgot
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The fl- derivatives are definitely not prodrugs. C-F bond stronk. More likely to be a metabolism prevention thing, or in this case, looking at the metabolites of modafinil, I guess there's a pretty decent chance it's to modify some affinity, prolly to increase lipophilicity?
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