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We observe reduction in dN/dS in low VAF (hemizygous or subclonal) mutations too! Agreed that it could be reduced selection, but it also could be due to inefficient selection (e.g. longer residence times of neutral mutations or rapid population expansion following transformation)pic.twitter.com/qlx4dVszHc
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@SusanneTilk presenting on the effect of the genome-wide mutation rate on patterns of positive and negative selection in cancer#SACB2018pic.twitter.com/ILUAyGx7ap
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