Great question. The circles are copied out from chromosomal DNA and sit alongside the chromosomes inside the nucleus. The mitochondria sit outside the nucleus and have their own DNA. But there are lots of intriguing links between mt and cancer (eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371788/ … )
Along with 23 pairs of chromosomes, some of our cells have mysterious circles of DNA. Here’s my @nytimes story on their emergence—and how they may accelerate cancer.https://www.nytimes.com/2019/11/20/science/dna-genetics-cancer.html …
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Good work as usual. Thanks
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In the 1970s and 1980s Bob Schimke's lab at Stanford showed that such double-minute chromosomes in drug-resistant tumor cells were amplified and active because they contained a DHFR gene conferring resistance to methotrexate.
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Let’s also circle back to some *earlier* work on circular DNA in normal human and worm cells that first discovered eccDNA from genic regions like Titin in muscle cellshttps://doi.org/10.1534/g3.117.300141 …
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Fascinating stuff. But these kind of discoveries make me even more wary of tools like CRISPR, when we just don’t know what we don’t know
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I for one am busy at work creating my army of Super Chimps, and Flying Spider Lemurs. We do our work for our lord and master, Skeletor.pic.twitter.com/rFGvMaMId2
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New doc u series on
#cancer coming to FYI Network Jan 4th. This is a game changerhttps://www.youtube.com/watch?v=HbFrO1WXKLM&feature=youtu.be …Thanks. Twitter will use this to make your timeline better. UndoUndo
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