Preskoči na sadržaj
Korištenjem servisa na Twitteru pristajete na korištenje kolačića. Twitter i partneri rade globalno te koriste kolačiće za analize, personalizaciju i oglase.

Za najbolje sučelje na Twitteru koristite Microsoft Edge ili instalirajte aplikaciju Twitter iz trgovine Microsoft Store.

  • Naslovnica Naslovnica Naslovnica, trenutna stranica.
  • O Twitteru

Spremljena pretraživanja

  • obriši
  • U ovom razgovoru
    Ovjeren akauntZaštićeni tweetovi @
Predloženi korisnici
  • Ovjeren akauntZaštićeni tweetovi @
  • Ovjeren akauntZaštićeni tweetovi @
  • Jezik: Hrvatski
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English
    • English UK
    • Español
    • Filipino
    • Français
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Български език
    • Русский
    • Српски
    • Українська мова
    • Ελληνικά
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Imate račun? Prijava
    Imate račun?
    · Zaboravili ste lozinku?

    Novi ste na Twitteru?
    Registrirajte se
Profil korisnika/ce careyjans
Carey Jansen
Carey Jansen
Carey Jansen
@careyjans

Tweets

Carey Jansen

@careyjans

MD/PhD at @emoryuniversity | tumor immunology @WinshipAtEmory | @HaydnKissick Lab | @behindthescope_ producer | @uva grad | opinions are my own | #DoubleDocs

Atlanta, GA
Vrijeme pridruživanja: veljača 2012.

Tweets

  • © 2020 Twitter
  • O Twitteru
  • Centar za pomoć
  • Uvjeti
  • Pravila o privatnosti
  • Imprint
  • Kolačići
  • Informacije o oglasima
Odbaci
Prethodni
Sljedeće

Idite na profil osobe

Spremljena pretraživanja

  • obriši
  • U ovom razgovoru
    Ovjeren akauntZaštićeni tweetovi @
Predloženi korisnici
  • Ovjeren akauntZaštićeni tweetovi @
  • Ovjeren akauntZaštićeni tweetovi @

Odjava

Blokiraj

  • Objavi Tweet s lokacijom

    U tweetove putem weba ili aplikacija drugih proizvođača možete dodati podatke o lokaciji, kao što su grad ili točna lokacija. Povijest lokacija tweetova uvijek možete izbrisati. Saznajte više

    Vaši popisi

    Izradi novi popis


    Manje od 100 znakova, neobavezno

    Privatnost

    Kopiraj vezu u tweet

    Ugradi ovaj Tweet

    Embed this Video

    Dodajte ovaj Tweet na svoje web-mjesto kopiranjem koda u nastavku. Saznajte više

    Dodajte ovaj videozapis na svoje web-mjesto kopiranjem koda u nastavku. Saznajte više

    Hm, došlo je do problema prilikom povezivanja s poslužiteljem.

    Integracijom Twitterova sadržaja u svoje web-mjesto ili aplikaciju prihvaćate Twitterov Ugovor za programere i Pravila za programere.

    Pregled

    Razlog prikaza oglasa

    Prijavi se na Twitter

    · Zaboravili ste lozinku?
    Nemate račun? Registrirajte se »

    Prijavite se na Twitter

    Niste na Twitteru? Registrirajte se, uključite se u stvari koje vas zanimaju, i dobivajte promjene čim se dogode.

    Registrirajte se
    Imate račun? Prijava »

    Dvosmjerni (slanje i primanje) kratki kodovi:

    Država Kod Samo za korisnike
    Sjedinjene Američke Države 40404 (bilo koje)
    Kanada 21212 (bilo koje)
    Ujedinjeno Kraljevstvo 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Irska 51210 Vodafone, O2
    Indija 53000 Bharti Airtel, Videocon, Reliance
    Indonezija 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italija 4880804 Wind
    3424486444 Vodafone
    » Pogledajte SMS kratke šifre za druge zemlje

    Potvrda

     

    Dobro došli kući!

    Vremenska crta mjesto je na kojem ćete provesti najviše vremena i bez odgode dobivati novosti o svemu što vam je važno.

    Tweetovi vam ne valjaju?

    Prijeđite pokazivačem preko slike profila pa kliknite gumb Pratim da biste prestali pratiti neki račun.

    Kažite mnogo uz malo riječi

    Kada vidite Tweet koji volite, dodirnite srce – to osobi koja ga je napisala daje do znanja da vam se sviđa.

    Proširite glas

    Najbolji je način da podijelite nečiji Tweet s osobama koje vas prate prosljeđivanje. Dodirnite ikonu da biste smjesta poslali.

    Pridruži se razgovoru

    Pomoću odgovora dodajte sve što mislite o nekom tweetu. Pronađite temu koja vam je važna i uključite se.

    Saznajte najnovije vijesti

    Bez odgode pogledajte o čemu ljudi razgovaraju.

    Pratite više onoga što vam se sviđa

    Pratite više računa da biste dobivali novosti o temama do kojih vam je stalo.

    Saznajte što se događa

    Bez odgode pogledajte najnovije razgovore o bilo kojoj temi.

    Ne propustite nijedan aktualni događaj

    Bez odgode pratite kako se razvijaju događaji koje pratite.

    Carey Jansen‏ @careyjans 11. pro 2019.
    • Prijavi Tweet

    I am so excited to share my FIRST, first author publication, “An intra-tumoral niche maintains and differentiates stem-like CD8 T-cells,” published today in @nature, detailing the project I’ve been working on in @HaydnKissick’s lab.https://www.nature.com/articles/s41586-019-1836-5 …

    10:17 - 11. pro 2019.
    • 172 proslijeđena tweeta
    • 938 oznaka „sviđa mi se”
    • Neil Carleton Naveed Tavakol John Animates Research Alvin Firda pensiunawati pcsrkkhlt Johan Henriksson Austin C Adegboyega Adewale
    45 replies 172 proslijeđena tweeta 938 korisnika označava da im se sviđa
      1. Novi razgovor
      2. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        In this paper, we report that an intratumoral immune niche, made up of stem-like CD8 T cells and antigen presenting cells, is required to support the CD8 T cell response to cancer.

        1 reply 0 proslijeđenih tweetova 13 korisnika označava da im se sviđa
        Prikaži ovu nit
      3. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Measuring T cell infiltration has been powerful in predicting outcomes in many cancers, but this association has been unclear in kidney cancers. Here, we show that high levels of infiltration CD8 T cells significantly predicts patient progression free survival.

        1 reply 0 proslijeđenih tweetova 12 korisnika označava da im se sviđa
        Prikaži ovu nit
      4. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Patients with more T cells progress 4x less rapidly than those with few T cells, which could have important implications for clinical care (Fig 1b). But we also wanted to ask a more basic question: Why do some patients’ tumors have many T cells, while others have so few?pic.twitter.com/U3sDXhox3E

        1 reply 0 proslijeđenih tweetova 12 korisnika označava da im se sviđa
        Prikaži ovu nit
      5. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        What we found was that tumor infiltrating T cells contain 2 important subpopulations: Tim3+ terminally differentiated (TD), effector like cells and TCF1+ stem-like CD8 T cells (Fig 1c).pic.twitter.com/l4tQTeeZNq

        1 reply 2 proslijeđena tweeta 14 korisnika označava da im se sviđa
        Prikaži ovu nit
      6. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        When sorted from human tumors, these stem-like cells consistently proliferate upon stimulation, while the TD cells lack proliferative potential. Upon division, stem-like cells upregulate checkpoint and effector molecules, suggesting their differentiation into TD cells (Fig 1e,g)pic.twitter.com/FAqKjCmi30

        1 reply 0 proslijeđenih tweetova 9 korisnika označava da im se sviđa
        Prikaži ovu nit
      7. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        That the stem-like cells give rise to the TD cells is also illustrated by the clonal overlap seen between these populations when their TCR repertoires are sequenced (Fig 1i). (Thank you to @AdaptiveBiotech for my young investigator grant to make this possible!)pic.twitter.com/diIfodyMNZ

        0 proslijeđenih tweetova 10 korisnika označava da im se sviđa
        Prikaži ovu nit
      8. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Interestingly, there was also clonal overlap between stem-like and TD populations in disparate locations within the same tumor (Ext Data 4g).

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
        Prikaži ovu nit
      9. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We also used RNAseq to examine these populations. The TD cells express high levels of checkpoints and effector molecules, while stem-like cells express higher levels of co-stim and survival genes (Fig 2a).pic.twitter.com/2PrYNlGpF5

        0 proslijeđenih tweetova 9 korisnika označava da im se sviđa
        Prikaži ovu nit
      10. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        These populations are analogous to those stem-like and TD populations seen in mouse chronic viral infx (Fig 2b).pic.twitter.com/B1wtqanjw6

        1 reply 0 proslijeđenih tweetova 9 korisnika označava da im se sviđa
        Prikaži ovu nit
      11. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Importantly, both stem-like and TD cells are distinct from human yellow fever specific memory & effector T cells – when compared to these populations, they are more similar to effector cells, reflecting their continued, active response in the presence of antigen (Ext Data 5a-e).pic.twitter.com/HcsRG1Aeyt

        0 proslijeđenih tweetova 7 korisnika označava da im se sviđa
        Prikaži ovu nit
      12. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        This finding—that a stem-like CD8 population resides *in* the tumor—surprising. In mouse models of chronic infection, analogous cells are only found in lymphoid tissue.

        1 reply 0 proslijeđenih tweetova 7 korisnika označava da im se sviđa
        Prikaži ovu nit
      13. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        So, we hypothesized that a lymphoid-like microenvironment may support these stem-like cells in the tumor and subsequently looked for antigen presenting cells (APCs) in the tumor tissue.

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
        Prikaži ovu nit
      14. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We found a strong correlation between tumor infiltrating CD8 T cells and dendritic cells (Fig 3b), a type of APC, which prompted us to use immunofluorescence to see the spatial relationship between these cells.

        1 reply 1 proslijeđeni tweet 8 korisnika označava da im se sviđa
        Prikaži ovu nit
      15. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We found that stem-like T cells were preferentially found in regions with dense aggregations of MHC-II+ cells (which are APCs), while the TD cells were more dispersed throughout the tissue (Fig 3c).pic.twitter.com/B1AIcBHNPe

        1 reply 1 proslijeđeni tweet 13 korisnika označava da im se sviđa
        Prikaži ovu nit
      16. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        This suggested to us that the stem-like cells were living in lymphoid-like niches with APCs, somewhat like setting up a lymph node like microenvironment in the tumor.

        1 reply 1 proslijeđeni tweet 13 korisnika označava da im se sviđa
        Prikaži ovu nit
      17. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We also quantified the immunofluorescence data we collected—creating ‘immunomaps’ that show the location of cells of interest and allowing for measurement of staining intensity in single cells (Fig 3d). For techniques, see Ext Data 6c and our methods section.pic.twitter.com/Ych0NwbMB4

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
        Prikaži ovu nit
      18. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We used these quantification techniques to correlate IF-based measurements of T cell infiltration with our measurements by flow cytometry in the same patients (Ext Data 9c), which confirmed that patients with high CD8 T cell infiltration by flow also had high infiltration by IF.pic.twitter.com/8MudW0cG1g

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
        Prikaži ovu nit
      19. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We also found that it was critical to sample >100 random 20x fields of view before there was a strong correlation w/ whole tissue analysis (Ext Data 9d). This highlights how vital it is to sample large areas of tumor to get an accurate quantification of infiltration into tumors.pic.twitter.com/fgukbe20Ru

        3 proslijeđena tweeta 19 korisnika označava da im se sviđa
        Prikaži ovu nit
      20. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        When we compared APC density across this cohort, patients w/o progressive disease had many areas with high APC density, whereas patients whose disease progressed had fewer of these areas (Fig 4f), reflecting an absence of stem-like T cell/APC niches in the tumor (Fig 4d, h).pic.twitter.com/QfDfy0YG36

        1 reply 1 proslijeđeni tweet 10 korisnika označava da im se sviđa
        Prikaži ovu nit
      21. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Stratifying patients into those with MHC-II dense or MHC-II sparse tumors, we find that PFS is improved in patients with MHC-II dense tumors (Fig 4g). This could indicate a mechanism of immune escape, where tumors prevent or destroy intratumoral immune niches.pic.twitter.com/eNeEKmYSgD

        1 reply 2 proslijeđena tweeta 14 korisnika označava da im se sviđa
        Prikaži ovu nit
      22. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        In summary, we found that tumor infiltrating T cells are comprised of functionally distinct subsets—TCF1+ stem-like cells and TD cells that express high levels of checkpoint and effector molecules.

        1 reply 1 proslijeđeni tweet 11 korisnika označava da im se sviđa
        Prikaži ovu nit
      23. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We propose that these stem-like cells give rise to TD cells, and that these stem-like cells require regions of dense APCs (perhaps similar to a T cell zone of a LN) to survive in the tumor.

        1 reply 1 proslijeđeni tweet 9 korisnika označava da im se sviđa
        Prikaži ovu nit
      24. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        While I focused on our findings in kidney cancer here, we found similar results in bladder and prostate cancers and TCF1+ TILs have been identified in other tumor types (e.g. Sade Feldman, Cell, 2018), suggesting that this model is relevant across multiple tumor types.

        1 reply 1 proslijeđeni tweet 10 korisnika označava da im se sviđa
        Prikaži ovu nit
      25. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        So, based on our results, we propose that the decline of intratumoral T cell responses may not be due to an accumulation of checkpoints or PDL1 expression (Ext Data 10), but rather, by the failure of stem-like CD8 T cells to be stimulated to produce many anti-tumor TD cells.

        1 reply 1 proslijeđeni tweet 20 korisnika označava da im se sviđa
        Prikaži ovu nit
      26. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Our finding that these nests of closely associated T cells and APCs are scarce in tumors progressing rapidly after surgery may also suggest that destruction or prevention of formation of these niches may be a novel mechanism of tumor immune evasion.

        1 reply 1 proslijeđeni tweet 13 korisnika označava da im se sviđa
        Prikaži ovu nit
      27. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        We think that further investigating the mechanisms of a) how and where stem-like cells originate and b) how tumors may destroy or inhibit these intratumoral immune niches will provide avenues for improving patient care in the future.

        0 proslijeđenih tweetova 7 korisnika označava da im se sviđa
        Prikaži ovu nit
      28. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Finally, none of this work would be possible without our funding sources, without very many wonderful colleagues and friends, and particularly and importantly without the kind contributions of our patients and their families—we could not do this with you!

        1 reply 0 proslijeđenih tweetova 10 korisnika označava da im se sviđa
        Prikaži ovu nit
      29. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Thank you to funding sources: @PCF_Science, @PCFnews, @NIH, @AdaptiveBiotech, Swim Across America, and The Cox Foundation.

        1 reply 1 proslijeđeni tweet 8 korisnika označava da im se sviđa
        Prikaži ovu nit
      30. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        Thank you to our wonderful coauthors and collaborators! @HaydnKissick @nataliya_pro_ @virajmaster @JennyCarlisleMD @DrMartinSanda @MariaAn09407310 @bilenma @sowalsky @chrisfilson @s_wilkinson88 (and all the other #twitterless friends!)

        0 proslijeđenih tweetova 11 korisnika označava da im se sviđa
        Prikaži ovu nit
      31. Carey Jansen‏ @careyjans 11. pro 2019.
        • Prijavi Tweet

        @EmoryUniversity @WinshipAtEmory @EmoryMedicine @emory_urology @EmoryMSTP @CancerBioEmory @laneygradschool @EmoryPathology @EmoryRollins @nciccr_gmb

        1 reply 0 proslijeđenih tweetova 9 korisnika označava da im se sviđa
        Prikaži ovu nit
      32. Kraj razgovora

    Čini se da učitavanje traje već neko vrijeme.

    Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.

      Sponzorirani tweet

      false

      • © 2020 Twitter
      • O Twitteru
      • Centar za pomoć
      • Uvjeti
      • Pravila o privatnosti
      • Imprint
      • Kolačići
      • Informacije o oglasima