Every seat with a <15 point Trump margin last held by a Republican. A 6 point Lesko victory, if held to the general election, puts all of these in play.
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At the very least, there is the opportunity to give these guys a good scare. Even if they don't get unseated, maybe some chill wind around their feet will make them take notice.
Probably not.
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Florida #19 has better blue candidates and the current 1st Republican has only been, a BS carrier for Trump