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  1. Balaji S. Srinivasan ‏@balajis Mar 22

    1/If you are using software to go after a legacy physical vertical, we are most excited if you do it "full stack". http://www.cdixon.org/2014/03/15/full-stack-startups …

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  2. Balaji S. Srinivasan ‏@balajis Mar 22

    2/With @counsyl, we found that one cannot live by bioinformatics alone. So built a full clinical lab + software + national salesforce.

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  3. Balaji S. Srinivasan ‏@balajis Mar 22

    3/Here is a video of our robotic genome factory: http://www.technologyreview.com/video/521121/innovators-under-35-balaji-srinivasan-cofounder-counsyl … Also: insurance coverage, clearances, clinical integration...

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  4. Balaji S. Srinivasan ‏@balajis Mar 22

    4/The reason to do full stack is that it's hard to replace just one layer of an outdated legacy stack. CAC & integration costs can kill.

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  5. Balaji S. Srinivasan ‏@balajis Mar 22

    5/For example, consider "restaurant powered by technology" vs "tech for restaurants". With code, reinvent industry and make better margins.

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    Balaji S. Srinivasan ‏@balajis Mar 22

    6/You cannot automate something till you've done it manually many times. You cannot abstract an API till you've seen many specific examples.

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    11:29 PM - 22 Mar 2014
    1. βρυκόλακαςαλχημιστής ‏@bitemyapp Mar 22

      @balajis you can avoid the necessity of specific examples if you understand the general principles of what is and is not kosher.

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    2. βρυκόλακαςαλχημιστής ‏@bitemyapp Mar 22

      @balajis to cherry-pick a near-at-hand example, the Monoid. "empty" and a binary associative operation. Definitionally. Delimits the API.

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    3. Balaji S. Srinivasan ‏@balajis Mar 22

      7/Need to build a site of the scale of http://Amazon.com  - and encounter all the problems - before you could do http://aws.amazon.com .

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    4. βρυκόλακαςαλχημιστής ‏@bitemyapp Mar 22

      @balajis leveraging both positive and negative space for design is necessary for excellence.

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    5. Balaji S. Srinivasan ‏@balajis Mar 22

      8/Reinventing agriculture? Build new kind of farm, w/ solar panels & self-driving tractors. Control all factors, show that code cuts costs.

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    6. Jordan S. Terry ‏@The_Analyst Mar 22

      @balajis how are we going to re-employ all the low-cost manual labor/repetitive-task folks when they're replaced with technology?

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    7. Balaji S. Srinivasan ‏@balajis Mar 22

      9/More examples of full stack startups.. Education: http://techcrunch.com/2014/03/18/former-googlers-altschool-raises-33m-from-founders-fund-and-a16z-to-reimagine-primary-education/ … Autos: http://www.forbes.com/sites/jimgorzelany/2014/02/27/why-teslas-vertical-manufacturing-move-is-manifest-destiny/ … Hospitality: http://www.fastcompany.com/3027107/punk-meet-rock-airbnb-brian-chesky-chip-conley …

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    8. Balaji S. Srinivasan ‏@balajis Mar 22

      10/By doing it end-to-end, you see things. First, sometimes a good reason beyond tradition (eg regulatory, logistical) for legacy practices.

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    9. Dan Farfan ‏@DanFarfan Mar 22

      @balajis Well, you can’t do those things WELL until .. what you said. ;-)

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    10. Dhiraj Kacker ‏@dhirajkacker Mar 22

      @balajis Telecom companies in India uniquely poised to disrupt payments market bcos of scale, brand & distributiion: http://dhirajkacker.wordpress.com/2012/05/18/airtel-money-is-potentially-revolutionary/ …

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    11. Balaji S. Srinivasan ‏@balajis Mar 22

      11/Second, your control of adjacent layers may eliminate the initial problem you were trying to solve. Analogous to: http://en.wikipedia.org/wiki/Telescoping_series …

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    12. Dan Farfan ‏@DanFarfan Mar 22

      .@balajis Another reason for N2N, you better realize the info model that everyone believes rules, constrains all from breakthroughs

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    13. Balaji S. Srinivasan ‏@balajis Mar 22

      12/Third, solving whole problem builds respect in your vertical. Now you can recruit best people. Their experience + your code = invincible.

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    14. Balaji S. Srinivasan ‏@balajis Mar 22

      13/Fourth, your margins improve nonlinearly once you control the full stack. Simply having all orders in DB from day one is transformative.

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